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  • KD/KO Validated

SYTL4 Polyclonal antibody

SYTL4 Polyclonal Antibody for WB, IP, IHC, ELISA

Host / Isotype

Rabbit / IgG


human, mouse and More (1)





Cat no : 12128-1-AP


Exophilin 2, Granuphilin, SLP4, synaptotagmin like 4, Synaptotagmin like protein 4, SYTL4

Tested Applications

Positive WB detected inHeLa cells, mouse pancreas tissue, U2OS cells
Positive IP detected inHEK-293 cells
Positive IHC detected inhuman breast cancer tissue
Note: suggested antigen retrieval with TE buffer pH 9.0; (*) Alternatively, antigen retrieval may be performed with citrate buffer pH 6.0

Recommended dilution

Western Blot (WB)WB : 1:500-1:3000
Immunoprecipitation (IP)IP : 0.5-4.0 ug for 1.0-3.0 mg of total protein lysate
Immunohistochemistry (IHC)IHC : 1:50-1:500
It is recommended that this reagent should be titrated in each testing system to obtain optimal results.
Sample-dependent, Check data in validation data gallery.

Product Information

12128-1-AP targets SYTL4 in WB, IP, IF, IHC, ELISA applications and shows reactivity with human, mouse samples.

Tested Reactivity human, mouse
Cited Reactivityhuman, rat
Host / Isotype Rabbit / IgG
Class Polyclonal
Type Antibody
Immunogen SYTL4 fusion protein Ag2772
Full Name synaptotagmin-like 4
Calculated Molecular Weight 671 aa, 76 kDa
Observed Molecular Weight76 kDa
GenBank Accession NumberBC014913
Gene Symbol SYTL4
Gene ID (NCBI) 94121
Conjugate Unconjugated
Form Liquid
Purification MethodAntigen affinity purification
Storage Buffer PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
Storage ConditionsStore at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage. 20ul sizes contain 0.1% BSA.

Background Information

SYTL4, also known as SLP4 or granuphilin, is a member of the synaptotagmin-like protein (Slp) family. Members of this family are characterized by presence of an N-terminal Slp homology domain (SHD), which functions as a Rab27-binding domain, and C-terminal tandem C2 domains, putative Ca(2+)-binding motifs. SYTL4 is specifically expressed on dense-core granules in certain neuroendocrine cells and negatively controls dense-core vesicle exocytosis through specific interaction with Rab27A. (PMID: 16481396; 16473610)


Product Specific Protocols
WB protocol for SYTL4 antibody 12128-1-APDownload protocol
IHC protocol for SYTL4 antibody 12128-1-APDownload protocol
IP protocol for SYTL4 antibody 12128-1-APDownload protocol
Standard Protocols
Click here to view our Standard Protocols



Nat Commun

Exosomes maintain cellular homeostasis by excreting harmful DNA from cells.

Authors - Akiko Takahashi

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Kinesin-1: A New Actor Involved in Platelet Secretion and Thrombus Stability.

Authors - Frédéric Adam


SYTL4 downregulates microtubule stability and confers paclitaxel resistance in triple-negative breast cancer.

Authors - Xi-Yu Liu
  • KD Validated

J Proteome Res

Identification of tyrosine-phosphorylated proteins associated with lung cancer metastasis using label-free quantitative analyses.

Authors - Wu Hsin-Yi HY

Biophys Rep

PMID: 30596141

Authors - Min Li