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SYTL4 Antibody 4 Publications

Rabbit Polyclonal| Catalog number: 12128-1-AP

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Con: 39 μg/150 μl

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Tested Applications

Applications:
WB, IP, IHC, ELISA
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SYTL4 Antibody IP HEK-293 cells 12128-1-AP

IP result of anti-SYTL4(IP:12128-1-AP, 4ug; Detection:12128-1-AP 1:300) with HEK-293 cells lysate 1600 ug

SYTL4 Antibody IHC human breast cancer tissue 12128-1-AP

Immunohistochemical analysis of paraffin-embedded human breast cancer using 12128-1-AP(SYTL4 antibody) at dilution of 1:50 (under 10x lens)

Species specificity:
human, mouse, rat
Positive IP detected in:
HEK-293 cells
Positive IHC detected in:
human breast cancer tissue

Note: suggested antigen retrieval with TE buffer pH 9.0; (*) Alternatively, antigen retrieval may be performed with citrate buffer pH 6.0
Recommended dilution:
IP : 0.5-4.0 ug for IP and 1:200-1:1000 for WB
IHC : 1:20-1:200
Sample-dependent, check data in Validation tab

Product Information

Source:
Rabbit
Purification method:
Antigen affinity purification
Isotype:
IgG
Storage:
PBS with 0.1% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information

Immunogen:
SYTL4 fusion protein Ag2772
Full name:
synaptotagmin-like 4
Calculated molecular weight:
671aa,76 kDa
Observed molecular weight:
76 kDa
GenBank accession number:
BC014913
Gene ID (NCBI):
94121
Gene symbol
SYTL4
Synonyms
Exophilin 2, Granuphilin, SLP4, synaptotagmin like 4, Synaptotagmin like protein 4, SYTL4

Background

SYTL4, also known as SLP4 or granuphilin, is a member of the synaptotagmin-like protein (Slp) family. Members of this family are characterized by presence of an N-terminal Slp homology domain (SHD), which functions as a Rab27-binding domain, and C-terminal tandem C2 domains, putative Ca(2+)-binding motifs. SYTL4 is specifically expressed on dense-core granules in certain neuroendocrine cells and negatively controls dense-core vesicle exocytosis through specific interaction with Rab27A. (PMID: 16481396; 16473610)


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