|Positive WB detected in||HEK-293 cells, HepG2 cells, mouse kidney tissue, mouse liver tissue, mouse lung tissue, mouse testis tissue|
|Positive IF detected in||HepG2 cells|
|Western Blot (WB)||WB : 1:500-1:1000|
|Immunofluorescence (IF)||IF : 1:10-1:100|
|Sample-dependent, check data in validation data gallery|
14424-1-AP targets TAX1BP1 in WB, IF,ELISA applications and shows reactivity with human, mouse samples.
|Tested Reactivity||human, mouse|
|Cited Reactivity||human, mouse|
|Host / Isotype||Rabbit / IgG|
|Immunogen||TAX1BP1 fusion protein Ag5789|
|Full Name||Tax1 (human T-cell leukemia virus type I) binding protein 1|
|Calculated molecular weight||91 kDa|
|Observed molecular weight||68 kDa, 85 kDa|
|GenBank accession number||BC050358|
|Gene ID (NCBI)||8887|
|Purification Method||Antigen affinity purification|
|Storage Buffer||PBS with 0.02% sodium azide and 50% glycerol pH 7.3.|
|Storage Conditions||Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage.|
TAX1BP1 (also named as T6BP and TXBP151) inhibits TNF-induced apoptosis by mediating the TNFAIP3 anti-apoptotic activity. It is degraded by caspase-3-like family proteins upon TNF-induced apoptosis. TAX1BP1 may also play a role in the pro-inflammatory cytokine IL-1 signaling cascade. TAX1BP1 binds TRAF6 but not TRAFs 1-5. TAX1BP1 has 4 isoforms with MW 65-68 kDa and 86-91 kDa. Western blot analysis showed that TAX1BP1 is expressed as an 86 kDa or a 68 kDa protein.
A20/TNFAIP3 Regulates the DNA Damage Response and Mediates Tumor Cell Resistance to DNA-Damaging Therapy.
Tetrandrine Prevents Bone Loss in Ovariectomized Mice by Inhibiting RANKL-Induced Osteoclastogenesis.
FIP200 controls the TBK1 activation threshold at SQSTM1/p62-positive condensates.
Selective Autophagy of Mitochondria on a Ubiquitin-Endoplasmic-Reticulum Platform.
TNF-induced necroptosis initiates early autophagy events via RIPK3-dependent AMPK activation, but inhibits late autophagy.
NF-κB Restricts Inflammasome Activation via Elimination of Damaged Mitochondria.