TAX1BP1 Polyclonal antibody

TAX1BP1 Polyclonal Antibody for IF, WB,ELISA

Host / Isotype

Rabbit / IgG

Reactivity

human, mouse

Applications

WB, IF,ELISA

Conjugate

Unconjugated

Cat no : 14424-1-AP

Synonyms

CALCOCO3, T6BP, Tax1 binding protein 1, TAX1BP1, TRAF6 binding protein, TXBP151



Tested Applications

Positive WB detected inHEK-293 cells, HepG2 cells, mouse kidney tissue, mouse liver tissue, mouse lung tissue, mouse testis tissue
Positive IF detected inHepG2 cells

Recommended dilution

ApplicationDilution
Western Blot (WB)WB : 1:500-1:1000
Immunofluorescence (IF)IF : 1:10-1:100
Sample-dependent, check data in validation data gallery

Product Information

14424-1-AP targets TAX1BP1 in WB, IF,ELISA applications and shows reactivity with human, mouse samples.

Tested Reactivity human, mouse
Cited Reactivity human, mouse
Host / Isotype Rabbit / IgG
Class Polyclonal
Type Antibody
Immunogen TAX1BP1 fusion protein Ag5789
Full Name Tax1 (human T-cell leukemia virus type I) binding protein 1
Calculated molecular weight 91 kDa
Observed molecular weight 68 kDa, 85 kDa
GenBank accession numberBC050358
Gene symbol TAX1BP1
Gene ID (NCBI) 8887
Conjugate Unconjugated
Form Liquid
Purification Method Antigen affinity purification
Storage Buffer PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
Storage ConditionsStore at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage.

Background Information

TAX1BP1 (also named as T6BP and TXBP151) inhibits TNF-induced apoptosis by mediating the TNFAIP3 anti-apoptotic activity. It is degraded by caspase-3-like family proteins upon TNF-induced apoptosis. TAX1BP1 may also play a role in the pro-inflammatory cytokine IL-1 signaling cascade. TAX1BP1 binds TRAF6 but not TRAFs 1-5. TAX1BP1 has 4 isoforms with MW 65-68 kDa and 86-91 kDa. Western blot analysis showed that TAX1BP1 is expressed as an 86 kDa or a 68 kDa protein.

Protocols

Product Specific Protocols
WB protocol for TAX1BP1 antibody 14424-1-APDownload protocol
IF protocol for TAX1BP1 antibody 14424-1-APDownload protocol
Standard Protocols
Click here to view our Standard Protocols

Publications

SpeciesApplicationTitle
human

Cancer Res

A20/TNFAIP3 Regulates the DNA Damage Response and Mediates Tumor Cell Resistance to DNA-Damaging Therapy.

Authors - Chuanzhen Yang
mouseWB

Front Pharmacol

Tetrandrine Prevents Bone Loss in Ovariectomized Mice by Inhibiting RANKL-Induced Osteoclastogenesis.

Authors - Zeyuan Zhong
mouseIF

Sci Rep

FIP200 controls the TBK1 activation threshold at SQSTM1/p62-positive condensates.

Authors - David Schlütermann
  • KD Validated
humanIF

Dev Cell

Selective Autophagy of Mitochondria on a Ubiquitin-Endoplasmic-Reticulum Platform.

Authors - Maria Zachari
mouseWB

Autophagy

TNF-induced necroptosis initiates early autophagy events via RIPK3-dependent AMPK activation, but inhibits late autophagy.

Authors - Wenxian Wu
mouseWB

Cell

NF-κB Restricts Inflammasome Activation via Elimination of Damaged Mitochondria.

Authors - Zhenyu Zhong