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TAX1BP1 Polyclonal antibody

TAX1BP1 Polyclonal Antibody for IF, WB, ELISA

Host / Isotype

Rabbit / IgG

Reactivity

human, mouse

Applications

WB, IF, ELISA

Conjugate

Unconjugated

Cat no : 14424-1-AP

Synonyms

CALCOCO3, T6BP, Tax1 binding protein 1, TAX1BP1, TRAF6 binding protein, TXBP151



Tested Applications

Positive WB detected inA549 cells, HeLa cells, HepG2 cells
Positive IF detected inHepG2 cells

Recommended dilution

ApplicationDilution
Western Blot (WB)WB : 1:1000-1:5000
Immunofluorescence (IF)IF : 1:10-1:100
It is recommended that this reagent should be titrated in each testing system to obtain optimal results.
Sample-dependent, Check data in validation data gallery.

Product Information

14424-1-AP targets TAX1BP1 in WB, IF, ELISA applications and shows reactivity with human, mouse samples.

Tested Reactivity human, mouse
Cited Reactivityhuman, mouse
Host / Isotype Rabbit / IgG
Class Polyclonal
Type Antibody
Immunogen TAX1BP1 fusion protein Ag5789
Full Name Tax1 (human T-cell leukemia virus type I) binding protein 1
Calculated Molecular Weight 91 kDa
Observed Molecular Weight 90 kDa
GenBank Accession NumberBC050358
Gene Symbol TAX1BP1
Gene ID (NCBI) 8887
RRIDAB_2198921
Conjugate Unconjugated
Form Liquid
Purification MethodAntigen affinity purification
Storage Buffer PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
Storage ConditionsStore at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage. 20ul sizes contain 0.1% BSA.

Background Information

TAX1BP1 (also named as T6BP and TXBP151) inhibits TNF-induced apoptosis by mediating the TNFAIP3 anti-apoptotic activity. It is degraded by caspase-3-like family proteins upon TNF-induced apoptosis. TAX1BP1 may also play a role in the pro-inflammatory cytokine IL-1 signaling cascade. TAX1BP1 binds TRAF6 but not TRAFs 1-5.

Protocols

Product Specific Protocols
WB protocol for TAX1BP1 antibody 14424-1-APDownload protocol
IF protocol for TAX1BP1 antibody 14424-1-APDownload protocol
Standard Protocols
Click here to view our Standard Protocols

Publications

SpeciesApplicationTitle
mouseWB

Cell

NF-κB Restricts Inflammasome Activation via Elimination of Damaged Mitochondria.

Authors - Zhenyu Zhong
WB

Mol Cell

PARP5A and RNF146 phase separation restrains RIPK1-dependent necroptosis

Authors - Shouqiao Hou
mouseWB

Redox Biol

A detrimental role of NLRP6 in host iron metabolism during Salmonella infection.

Authors - Qifeng Deng
humanIF

Autophagy

Inhibition of the SEC61 translocon by mycolactone induces a protective autophagic response controlled by EIF2S1-dependent translation that does not require ULK1 activity.

Authors - Belinda S Hall
mouseWB

Autophagy

TNF-induced necroptosis initiates early autophagy events via RIPK3-dependent AMPK activation, but inhibits late autophagy.

Authors - Wenxian Wu
humanIF

Dev Cell

Selective Autophagy of Mitochondria on a Ubiquitin-Endoplasmic-Reticulum Platform.

Authors - Maria Zachari