TCN1 Polyclonal antibody

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• TCN1 Polyclonal antibody (16078-1-AP)

TCN1 Polyclonal Antibody for WB, IHC, ELISA

Cat No. 16078-1-AP Copied!

Publications (6)

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Host / Isotype

Rabbit / IgG

Reactivity

human

Applications

WB, IHC, ELISA

Synonyms

Haptocorrin, HC, Protein R, TC1, TC-1

• 

  WB analysis of human saliva using 16078-1-AP

  human saliva were subjected to SDS PAGE followed by western blot with 16078-1-AP (TCN1 Antibody) at dilution of 1:2000 incubated at 4 degree celsius over night.

  This validation data has been generated in-house and reviewed by Proteintech scientists. Find out more on our antibody validation policy
• 

  IHC staining of human tonsillitis using 16078-1-AP

  Immunohistochemical analysis of paraffin-embedded human tonsillitis tissue slide using 16078-1-AP (TCN1 antibody) at dilution of 1:400 (under 20x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0).

  This validation data has been generated in-house and reviewed by Proteintech scientists. Find out more on our antibody validation policy
• 

  IHC staining of human tonsillitis using 16078-1-AP

  Immunohistochemical analysis of paraffin-embedded human tonsillitis tissue slide using 16078-1-AP (TCN1 antibody) at dilution of 1:400 (under 20x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0).

  This validation data has been generated in-house and reviewed by Proteintech scientists. Find out more on our antibody validation policy
• 

  IHC staining of human tonsillitis using 16078-1-AP

  Immunohistochemical analysis of paraffin-embedded human tonsillitis tissue slide using 16078-1-AP (TCN1 Antibody) at dilution of 1:50 (under 10x lens).

  This validation data has been generated in-house and reviewed by Proteintech scientists. Find out more on our antibody validation policy
• 

  IHC staining of human tonsillitis using 16078-1-AP

  Immunohistochemical analysis of paraffin-embedded human tonsillitis tissue slide using 16078-1-AP (TCN1 Antibody) at dilution of 1:50 (under 40x lens).

  This validation data has been generated in-house and reviewed by Proteintech scientists. Find out more on our antibody validation policy

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Tested Applications

• Positive WB detected in: human saliva
• Positive IHC detected in: human tonsillitis tissue; Note: suggested antigen retrieval with TE buffer pH 9.0; (*) Alternatively, antigen retrieval may be performed with citrate buffer pH 6.0

Recommended dilution

• Western Blot (WB): WB : 1:1000-1:4000
• Immunohistochemistry (IHC): IHC : 1:200-1:800

It is recommended that this reagent should be titrated in each testing system to obtain optimal results.

Sample-dependent, Check data in validation data gallery.

Product Information

16078-1-AP targets TCN1 in WB, IHC, ELISA applications and shows reactivity with human samples.

• Tested Reactivity: human
• Cited Reactivity: human
• Host / Isotype: Rabbit / IgG
• Class: Polyclonal
• Type: Antibody
• Immunogen:

  CatNo: Ag9072

  Product name: Recombinant human TCN1 protein

  Source: e coli.-derived, PGEX-4T

  Tag: GST

  Domain: 1-339 aa of BC018632

  Sequence: SRLSDVSSGELALIILALGVCRNAEENLIYDYHLIDKLENKFQAEIENMEAHNGTPLTNYYQLSLDVLALCLFNGNYSTAEVVNHFTPENKNYYFGSQFSVDTGAMAVLALTCVKKSLINGQIKADEGSLKNISIYTKSLVEKILSEKKENGLIGNTFSTGEAMQALFVSSDYYNENDWNCQQTLNTVLTEISQGAFSNPNAAAQVLPALMGKTFLDINKDSSCVSASGNFNISADEPITVTPPDSQSYISVNYSVRINETYFTNVTVLNGSVFLSVMEKAQKMNDTIFGFTMEERSWGPYITCIQGLCANNNDRTYWELLSGGEPLSQGAGSYVVRNG

• Full Name: transcobalamin I (vitamin B12 binding protein, R binder family)
• Calculated Molecular Weight: 433 aa, 48 kDa
• Observed Molecular Weight: 65-70 kDa
• GenBank Accession Number: BC018632
• Gene Symbol: TCN1
• Gene ID (NCBI): 6947
• RRID: AB_2878215
• Conjugate: Unconjugated
• Form: Liquid
• Purification Method: Antigen affinity purification
• UNIPROT ID: P20061
• Storage Buffer: PBS with 0.02% sodium azide and 50% glycerol, pH 7.3.
• Storage Conditions: Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20^oC storage. 20ul sizes contain 0.1% BSA.

Publications

What published studies show

The TCN1 Polyclonal antibody (Cat# 16078-1-AP) has 6 citations published in Advanced Science, Science Advances, International Immunopharmacology, Journal of Inflammation Research, Pathology Research and Practice, and Journal of Molecular Histology. Research fields span pancreatic ductal adenocarcinoma (perineural invasion), psoriasis (autoimmunity and NF-κB signaling), sepsis-induced acute lung injury, and non-small cell lung cancer (glycolysis and histone lactylation). Applications include WB and IHC in human samples.

Automatically generated from the 6 publication citations by Able AI.

• Human
• Mouse
• Rat
• Monkey
• Pig

Species	Application	Title
		Adv Sci (Weinh); Vitamin D Binding Protein, a Ligand of Integrin beta 1, Motivates Both Tumor Cells and Schwann Cells to Promote Perineural Invasion in Pancreatic Ductal Adenocarcinoma; Authors - Shan Zhang
human	WB,IHC	Sci Adv; Transcobalamin 1 is a keratinocyte-derived autoantigen driving psoriasis through T helper 17 cell activation.; Authors - Jing Wang
human	IHC	Int Immunopharmacol; TCN1 as an inflammatory regulator in psoriasis: Activation of the NF-κB pathway and potential therapeutic target; Authors - Jian Huang
human	WB	J Inflamm Res; Identification of Biomarkers for Sepsis-Induced Acute Lung Injury Through Bioinformatics and Machine Learning Approaches, with Experimental Validation.; Authors - Yannian Luo
		Pathol Res Pract; TCN1 knockdown inhibits the progression and glycolysis of non-small cell lung cancer via regulating B3GNT3.; Authors - Hui Zhou
human	WB,IHC	J Mol Histol; Histone H3K18 lactylation promotes malignancy progression in non-small cell lung cancer through TCN1 upregulation.; Authors - Yinhua Wang