TIMP2 Recombinant antibody, PBS Only

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  WB analysis using 83938-3-RR (same clone as 83938-3-PBS)

  Various lysates were subjected to SDS PAGE followed by western blot with 83938-3-RR (TIMP2 antibody) at dilution of 1:5000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 83938-3-PBS in a different storage buffer formulation.

TIMP2 Uni-rAb^TM Recombinant Antibody for WB, Indirect ELISA

Cat No. 83938-3-PBS

Clone No.243160E10

Host / Isotype

Rabbit / IgG

Reactivity

human

Applications

WB, Indirect ELISA

Synonyms

TIMP-2, CSC 21K, CSC-21K, Metalloproteinase inhibitor 2, TIMP 2

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Product Information

83938-3-PBS targets TIMP2 in WB, Indirect ELISA applications and shows reactivity with human samples.

• Tested Reactivity: human
• Host / Isotype: Rabbit / IgG
• Class: Recombinant
• Type: Antibody
• Immunogen: TIMP2 fusion protein Eg0430
• Full Name: TIMP metallopeptidase inhibitor 2
• Calculated Molecular Weight: 220 aa, 24 kDa
• Observed Molecular Weight: 21-24 kDa
• GenBank Accession Number: BC052605
• Gene Symbol: TIMP2
• Gene ID (NCBI): 7077
• Conjugate: Unconjugated
• Form: Liquid
• Purification Method: Protein A purification
• UNIPROT ID: P16035
• Storage Buffer: PBS only, pH 7.3.
• Storage Conditions: Store at -80°C.

Background Information

The TIMPs are natural highly specific endogenous inhibitors of MMPs. Human TIMP family consists of four 21-28 kDa proteins known as TIMP1, TIMP2, TIMP3, and TIMP4 encoded by four paralogous genes.TIMPs are vital to the maintenance of ECM homeostasis primarily through their MMP inhibitory functions. TIMP2, a member of the TIMP family, regulates the proteolytic activity of all MMPs and is involved in cell differentiation, growth, migration, angiogenesis, and apoptosis. Urinary TIMP2 has been recently recognized as an early biomarker to predict Acute kidney injury (AKI) in critically ill patients.