|Positive WB detected in||RAW 264.7 cells, human brain tissue, mouse thymus tissue, Jurkat cells, HT-1080 cells|
|Western Blot (WB)||WB : 1:500-1:2000|
|Sample-dependent, check data in validation data gallery|
The immunogen of 22240-1-AP is TLR6 Fusion Protein expressed in E. coli.
|Tested Reactivity||human, mouse|
|Host / Isotype||Rabbit / IgG|
|Immunogen||TLR6 fusion protein Ag17686|
|Full Name||toll-like receptor 6|
|Calculated molecular weight||480 aa, 56 kDa|
|Observed molecular weight||95-110 kDa|
|GenBank accession number||BC111755|
|Gene ID (NCBI)||10333|
|Purification Method||Antigen affinity purification|
|Storage Buffer||PBS with 0.02% sodium azide and 50% glycerol pH 7.3.|
|Storage Conditions||Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage.|
TLR6, also known as CD286, belongs to the Toll-like receptor (TLR) family which are important in the innate immune response to pathogens. TLRs are highly conserved from Drosophila to human and share structural and functional similarities. TLR6 can form a heterodimer with TLR2. TLR6 and TLR2 both are recruited to the macrophage phagosome, where they recognize peptidoglycan, a Gram-positive pathogen component (PMID: 11095740). TLR6 interacts with CD36, following CD36 stimulation by oxLDL or amyloid-beta 42, and forms a heterodimer with TLR4. The trimeric complex is internalized and triggers inflammatory response.
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