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  • KD/KO Validated

TLR6 Polyclonal antibody

TLR6 Polyclonal Antibody for WB, ELISA

Host / Isotype

Rabbit / IgG

Reactivity

human, mouse

Applications

WB, ELISA

Conjugate

Unconjugated

Cat no : 22240-1-AP

Synonyms

CD286, TLR6, toll like receptor 6



Tested Applications

Positive WB detected inRAW 264.7 cells, human brain tissue, mouse thymus tissue, Jurkat cells, HT-1080 cells

Recommended dilution

ApplicationDilution
Western Blot (WB)WB : 1:500-1:2000
It is recommended that this reagent should be titrated in each testing system to obtain optimal results.
Sample-dependent, check data in validation data gallery

Product Information

22240-1-AP targets TLR6 in WB, ELISA applications and shows reactivity with human, mouse samples.

Tested Reactivity human, mouse
Cited Reactivityhuman, mouse
Host / Isotype Rabbit / IgG
Class Polyclonal
Type Antibody
Immunogen TLR6 fusion protein Ag17686
Full Name toll-like receptor 6
Calculated molecular weight 480 aa, 56 kDa
Observed molecular weight 95-110 kDa
GenBank accession numberBC111755
Gene symbol TLR6
Gene ID (NCBI) 10333
RRIDAB_11232032
Conjugate Unconjugated
Form Liquid
Purification Method Antigen affinity purification
Storage Buffer PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
Storage ConditionsStore at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage. 20ul sizes contain 0.1% BSA.

Background Information

TLR6, also known as CD286, belongs to the Toll-like receptor (TLR) family which is important in the innate immune response to pathogens. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. TLR6 can form a heterodimer with TLR2. TLR6 and TLR2 both are recruited to the macrophage phagosome, where they recognize peptidoglycan, a Gram-positive pathogen component (PMID: 11095740). TLR6 interacts with CD36, following CD36 stimulation by oxLDL or amyloid-beta 42, and forms a heterodimer with TLR4. The trimeric complex is internalized and triggers an inflammatory response.

Protocols

Product Specific Protocols
WB protocol for TLR6 antibody 22240-1-APDownload protocol
Standard Protocols
Click here to view our Standard Protocols

Publications

SpeciesApplicationTitle
mouseWB

ACS Nano

Biomimetic Nanomedicine-Triggered in Situ Vaccination for Innate and Adaptive Immunity Activations for Bacterial Osteomyelitis Treatment.

Authors - Han Lin
human,mouseWB

BMC Med

HBeAg mediates inflammatory functions of macrophages by TLR2 contributing to hepatic fibrosis.

Authors - Xiaoyu Xie
  • KD Validated
humanWB

J Med Chem

Design, Synthesis, and Structure-Activity Relationship of N-Aryl-N'-(thiophen-2-yl)thiourea Derivatives as Novel and Specific Human TLR1/2 Agonists for Potential Cancer Immunotherapy.

Authors - Zhipeng Chen
human

Bioorg Chem

Synthesis, evaluation and molecular dynamics study of human toll-like receptor 2/6 specific monoacyl lipopeptides as candidate immunostimulants

Authors - Yueyue Zhu
humanWB

Eur J Med Chem

Structure-activity relationship study and biological evaluation of SAC-Garlic acid conjugates as novel anti-inflammatory agents.

Authors - Jingjie Bi
humanWB

Pediatr Infect Dis J

Toll-Like Receptor 6 V327M Polymorphism is Associated with an Increased Risk of Klebsiella pneumoniae Infection.

Authors - Haiou Yang