Biotin-conjugated TMED1 Recombinant monoclonal antibody

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• Biotin-conjugated TMED1 Recombinant monoclonal antibody (Biotin-87837)

TMED1 Uni-rAb^® Recombinant Antibody for IHC

Cat No. Biotin-87837

Clone No.253497F4

Host / Isotype

Rabbit / IgG

Reactivity

human

Applications

IHC

Synonyms

IL1RL1L, IL1RL1LG, Interleukin-1 receptor-like 1 ligand, p24 family protein gamma-1, p24gamma1

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  IHC staining of Human lung cancer （Adenocarcinoma） using Biotin-87837

  Immunohistochemical analysis of paraffin-embedded Human lung cancer (Adenocarcinoma) slide using Biotin-87837 (TMED1 antibody) at dilution of 1:200 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0).

  This validation data has been generated in-house and reviewed by Proteintech scientists. Find out more on our antibody validation policy

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Tested Applications

• Positive IHC detected in: Human lung cancer （Adenocarcinoma）; Note: suggested antigen retrieval with TE buffer pH 9.0; (*) Alternatively, antigen retrieval may be performed with citrate buffer pH 6.0

Recommended dilution

• Immunohistochemistry (IHC): IHC : 1:50-1:500

It is recommended that this reagent should be titrated in each testing system to obtain optimal results.

Sample-dependent, Check data in validation data gallery.

Product Information

Biotin-87837 targets TMED1 in IHC applications and shows reactivity with human samples.

• Tested Reactivity: human
• Host / Isotype: Rabbit / IgG
• Class: Recombinant
• Type: Antibody
• Immunogen:

  CatNo: Eg5903

  Product name: Recombinant human TMED1 protein

  Source: mammalian cells-derived, V37

  Tag: C-rFc

  Domain: 24-194 aa of NM_006858

  Sequence: AGPPPIQDGEFTFLLPAGRKQCFYQSAPANASLETEYQVIGGAGLDVDFTLESPQGVLLVSESRKADGVHTVEPTEAGDYKLCFDNSFSTISEKLVFFELIFDSLQDDEEVEGWAEAVEPEEMLDVKMEDIKESIETMRTRLERSIQMLTLLRAFEARDRNLQEGNLERVN

• Full Name: transmembrane emp24 protein transport domain containing 1
• Calculated Molecular Weight: 25 kDa
• GenBank Accession Number: NM_006858
• Gene Symbol: TMED1
• Gene ID (NCBI): 11018
• Conjugate: Biotin
• Form: Liquid
• Purification Method: Protein A purification
• UNIPROT ID: Q13445
• Storage Buffer: PBS with 50% glycerol, 0.05% Proclin300, 0.5% BSA, pH 7.3.
• Storage Conditions: Store at -20°C. Avoid exposure to light. Stable for one year after shipment. Aliquoting is unnecessary for -20^oC storage.

Background Information

Transmembrane p24 trafficking protein 1 (TMED1) belongs to the TMED protein family, also known as the p24 family, and plays a part in protein vesicular trafficking. As the critical regulator of protein trafficking along the secretory pathway, the TMED proteins influence the composition, structure, and function of the endoplasmic reticulum and the Golgi apparatus. Disruption of the secretory pathway could affect cell differentiation and survival, ultimately resulting in disease.(PMID: 38392302)