Product Information
24634-1-PBS targets TMPRSS11D in WB, Indirect ELISA applications and shows reactivity with human samples.
| Tested Reactivity | human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen |
CatNo: Ag17841 Product name: Recombinant human TMPRSS11D protein Source: e coli.-derived, PGEX-4T Tag: GST Domain: 47-352 aa of BC125195 Sequence: SYFYRSSFQLLNVEYNSQLNSPATQEYRTLSGRIESLITKTFKESNLRNQFIRAHVAKLRQDGSGVRADVVMKFQFTRNNNGASMKSRIESVLRQMLNNSGNLEINPSTEITSLTDQAAANWLINECGAGPDLITLSEQRILGGTEAEEGSWPWQVSLRLNNAHHCGGSLINNMWILTAAHCFRSNSNPRDWIATSGISTTFPKLRMRVRNILIHNNYKSATHENDIALVRLENSVTFTKDIHSVCLPAATQNIPPGSTAYVTGWGAQEYAGHTVPELRQGQVRIISNDVCNAPHSYNGAILSGML Predict reactive species |
| Full Name | transmembrane protease, serine 11D |
| Calculated Molecular Weight | 418 aa, 46 kDa |
| Observed Molecular Weight | 46 kDa |
| GenBank Accession Number | BC125195 |
| Gene Symbol | TMPRSS11D |
| Gene ID (NCBI) | 9407 |
| RRID | AB_3742119 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification Method | Antigen affinity purification |
| UNIPROT ID | O60235 |
| Storage Buffer | PBS only, pH 7.3. |
| Storage Conditions | Store at -80°C. |
Background Information
TMPRSS11D, also known as human airway trypsin-like protease (HAT), is a type II transmembrane serine protease that plays a crucial role in various biological processes, including viral infections and cancer progression. This protease is expressed in the epithelial cells of the respiratory tract and has been implicated in the activation of several viruses, such as SARS-CoV-2. In addition to its role in viral infections, TMPRSS11D has also been involved in cancer progression. High expression levels of TMPRSS11D have been associated with poor overall survival in non-small cell lung cancer. This suggests that TMPRSS11D may contribute to tumor growth and metastasis, making it a potential biomarker and therapeutic target in oncology. (PMID: 28086212, PMID: 40348740)
