Osteoprotegerin Polyclonal antibody

Osteoprotegerin Polyclonal Antibody for WB, ELISA

Host / Isotype

Rabbit / IgG

Reactivity

human

Applications

WB, ELISA

Conjugate

Unconjugated

Publications

1

Cat no : 11534-1-AP

Synonyms

OCIF, OPG, Osteoprotegerin, TNFRSF11B, TR1

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Validation Data Gallery

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  WB analysis of human milk using 11534-1-AP

  human milk was subjected to SDS PAGE followed by western blot with 11534-1-AP (Osteoprotegerin antibody) at dilution of 1:500 incubated at room temperature for 1.5 hours.

• 

  WB analysis of human milk using 11534-1-AP

  human milk was subjected to SDS PAGE followed by western blot with 11534-1-AP (Osteoprotegerin antibody) at dilution of 1:500 incubated at room temperature for 1.5 hours.

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Tested Applications

• Positive WB detected in: human milk

Recommended dilution

• Western Blot (WB): WB : 1:500-1:1000

It is recommended that this reagent should be titrated in each testing system to obtain optimal results.

Sample-dependent, Check data in validation data gallery.

Published Applications

• WB: See 1 publications below

Product Information

11534-1-AP targets Osteoprotegerin in WB, ELISA applications and shows reactivity with human samples.

• Tested Reactivity: human
• Cited Reactivity: human
• Host / Isotype: Rabbit / IgG
• Class: Polyclonal
• Type: Antibody
• Immunogen: Osteoprotegerin fusion protein Ag2139
• Full Name: tumor necrosis factor receptor superfamily, member 11b
• Calculated Molecular Weight: 401 aa, 46 kDa
• Observed Molecular Weight: 56 kDa
• GenBank Accession Number: BC030155
• Gene Symbol: TNFRSF11B
• Gene ID (NCBI): 4982
• Conjugate: Unconjugated
• Form: Liquid
• Purification Method: Antigen affinity purification
• Storage Buffer: PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
• Storage Conditions: Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20^oC storage. 20ul sizes contain 0.1% BSA.

Background Information

Osteoprotegerin (OPG), also known as tumor necrosis factor receptor superfamily member 11B (TNFRSF11B) and osteoclastogenesis inhibitory factor (OCIF), belongs to the tumor necrosis factor (TNF) receptor superfamily. By binding to RANKL, OPG inhibits osteoclastic activity and promoting bone formationis. OPG plays a key role on cell survival by inhibiting TRAIL-induced apoptosis. OPG also is involved in vascular biology, fibrosis, immunity, EMT, and the apoptosis of cancer cells (PMID: 35523775).

Publications

Species	Application	Title
human	WB	Anal Cell Pathol (Amst); Cartilage Damage Pathological Characteristics of Diabetic Neuropathic Osteoarthropathy; Authors - Pei-Long Liu