Product Information
34301-1-PBS targets TOX in WB, Indirect ELISA applications and shows reactivity with human samples.
| Tested Reactivity | human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen |
CatNo: Ag41257 Product name: Recombinant human TOX protein Source: e coli.-derived, PGEX-4T Tag: GST Domain: 50-235 aa of BC016665 Sequence: DYVPASQSYPGPSLESEDFNIPPITPPSLPDHSLVHLNEVESGYHSLCHPMNHNGLLPFHPQNMDLPEITVSNMLGQDGTLLSNSISVMPDIRNPEGTQYSSHPQMAAMRPRGQPADIRQQPGMMPHGQLTTINQSQLSAQLGLNMGGSNVPHNSPSPPGSKSATPSPSSSVHEDEGDDTSKINGG Predict reactive species |
| Full Name | thymocyte selection-associated high mobility group box |
| Calculated Molecular Weight | 526 aa, 58 kDa |
| Observed Molecular Weight | 57 kDa, 63 kDa |
| GenBank Accession Number | BC016665 |
| Gene Symbol | TOX |
| Gene ID (NCBI) | 9760 |
| RRID | AB_3743187 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification Method | Antigen affinity Purification |
| UNIPROT ID | O94900 |
| Storage Buffer | PBS only, pH 7.3. |
| Storage Conditions | Store at -80°C. |
Background Information
Thymocyte selection-associated high-mobility group box (TOX) is a DNA-binding factor that can regulate transcription by modifying local chromatin structure and modulating the formation of multi-protein complexes. TOX has multiple roles in the development of the adaptive immune system including development of CD4 T cells, NK cells and lymph node organogenesis (PMID: 35485425). Two bands detected at ~63 kDa and ~57kDa were presumed to be the unmodified form and the post-translationally form of TOX, respectively,(PMID: 32106280).
