TRPV1 Polyclonal antibody

TRPV1 Polyclonal Antibody for IHC, WB, ELISA

Host / Isotype

Rabbit / IgG


human, rat, mouse





Cat no : 22686-1-AP


Capsaicin receptor, Osm 9 like TRP channel 1, OTRPC1, TRPV1, Vanilloid receptor 1, VR1

Tested Applications

Positive WB detected inPC-12 cells
Positive IHC detected inhuman skin tissue, mouse skin tissue, human colon tissue
Note: suggested antigen retrieval with TE buffer pH 9.0; (*) Alternatively, antigen retrieval may be performed with citrate buffer pH 6.0

Recommended dilution

Western Blot (WB)WB : 1:500-1:2000
Immunohistochemistry (IHC)IHC : 1:50-1:500
It is recommended that this reagent should be titrated in each testing system to obtain optimal results.
Sample-dependent, Check data in validation data gallery.

Product Information

The immunogen of 22686-1-AP is TRPV1 Fusion Protein expressed in E. coli.

Tested Reactivity human, rat, mouse
Cited Reactivityhuman, mouse, rat
Host / Isotype Rabbit / IgG
Class Polyclonal
Type Antibody
Immunogen TRPV1 fusion protein Ag18583
Full Name transient receptor potential cation channel, subfamily V, member 1
Calculated Molecular Weight 839 aa, 95 kDa
Observed Molecular Weight 95 kDa
GenBank Accession NumberBC132820
Gene Symbol TRPV1
Gene ID (NCBI) 7442
Conjugate Unconjugated
Form Liquid
Purification MethodAntigen affinity purification
Storage Buffer PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
Storage ConditionsStore at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage. 20ul sizes contain 0.1% BSA.

Background Information

TRPV1, also named as VR1 or OTRPC1, belongs to the transient receptor potential (TRP) family and TRPV subfamily (PMID: 17579562). TRPV1 is a ligand-activated non-selective calcium permeant cation channel expressed predominantly by sensory neurons (PMID: 10821274). It is involved in detection of noxious chemical and thermal stimuli. TRPV1 plays an important role in inflammatory thermal hyperalgesia (PMID: 10764638; 10821274).


Product Specific Protocols
WB protocol for TRPV1 antibody 22686-1-APDownload protocol
IHC protocol for TRPV1 antibody 22686-1-APDownload protocol
Standard Protocols
Click here to view our Standard Protocols



Acta Pharmacol Sin

PMID: 29188798

Authors - Su-Shan Zhang

J Neurosci

Phosphorylation of TRPV1 S801 Contributes to Modality-Specific Hyperalgesia in Mice.

Authors - John Joseph


Dietary capsaicin and antibiotics act synergistically to reduce non-alcoholic fatty liver disease induced by high fat diet in mice.

Authors - Jingjuan Hu

Biomed Pharmacother

Suhuang antitussive capsule inhibits NLRP3 inflammasome activation and ameliorates pulmonary dysfunction via suppression of endoplasmic reticulum stress in cough variant asthma.

Authors - Weiwei Qin

Biomed Pharmacother

Qingfei oral liquid alleviates airway hyperresponsiveness and mucus hypersecretion via TRPV1 signaling in RSV-infected asthmatic mice.

Authors - Xiaoping Jing

Eur J Pharmacol

Spinophilin negatively controlled the function of transient receptor potential vanilloid 1 in dorsal root ganglia neurons of mice.

Authors - Zhen Guo