Product Information
87700-3-PBS targets TSPAN8 in WB, IHC, Indirect ELISA applications and shows reactivity with human samples.
| Tested Reactivity | human |
| Host / Isotype | Rabbit / IgG |
| Class | Recombinant |
| Type | Antibody |
| Immunogen |
CatNo: Eg7574 Product name: Recombinant human TSPAN8 protein Source: mammalian cells-derived, V37 Tag: C-rFc Domain: 110-205 aa of NM_004616.2 Sequence: KSKSDRIVNETLYENTKLLSATGESEKQFQEAIIVFQEEFKCCGLVNGAADWGNNFQHYPELCACLDKQRPCQSYNGKQVYKETCISFIKDFLAKN Predict reactive species |
| Full Name | tetraspanin 8 |
| Calculated Molecular Weight | 26 kDa |
| Observed Molecular Weight | 27 kDa |
| GenBank Accession Number | NM_004616.2 |
| Gene Symbol | TSPAN8 |
| Gene ID (NCBI) | 7103 |
| RRID | AB_3745705 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification Method | Protein A purification |
| UNIPROT ID | P19075 |
| Storage Buffer | PBS only, pH 7.3. |
| Storage Conditions | Store at -80°C. |
Background Information
TSPAN8 is a membrane protein of the tetraspanin superfamily, which are characterized by the presence of four conserved transmembrane regions. Tetraspanins have been involved in diverse processes such as cell activation and proliferation, adhesion and motility, differentiation, and cancer. TSPAN8 and CD151 coordinately promote metastasis, where Tspan8 overrides the adhesive features of CD151 by recruiting integrins out of adhesion into motility promoting complexes (PMID: 23683890). TSPAN8 contributes to molecular pathways of exosome-induced endothelial cell activation (PMID: 20124479).
