Telethonin Polyclonal antibody, PBS Only

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• Telethonin Polyclonal antibody, PBS Only (16104-1-PBS)

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  WB analysis using 16104-1-AP (same clone as 16104-1-PBS)

  Various lysates were subjected to SDS PAGE followed by western blot with 16104-1-AP (Telethonin antibody) at dilution of 1:2000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 16104-1-PBS in a different storage buffer formulation.

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  IHC staining of mouse heart using 16104-1-AP (same clone as 16104-1-PBS)

  Immunohistochemical analysis of paraffin-embedded mouse heart tissue slide using 16104-1-AP (Telethonin antibody) at dilution of 1:200 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 16104-1-PBS in a different storage buffer formulation.

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  IHC staining of mouse skeletal muscle using 16104-1-AP (same clone as 16104-1-PBS)

  Immunohistochemical analysis of paraffin-embedded mouse skeletal muscle tissue slide using 16104-1-AP (Telethonin antibody) at dilution of 1:200 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 16104-1-PBS in a different storage buffer formulation.

Telethonin Polyclonal Antibody for WB, IHC, Indirect ELISA

Cat No. 16104-1-PBS

Host / Isotype

Rabbit / IgG

Reactivity

human, mouse, rat

Applications

WB, IHC, Indirect ELISA

Synonyms

TCAP, CMD1N

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Product Information

16104-1-PBS targets Telethonin in WB, IHC, Indirect ELISA applications and shows reactivity with human, mouse, rat samples.

• Tested Reactivity: human, mouse, rat
• Host / Isotype: Rabbit / IgG
• Class: Polyclonal
• Type: Antibody
• Immunogen:

  CatNo: Ag9014

  Product name: Recombinant human TCAP protein

  Source: e coli.-derived, PGEX-4T

  Tag: GST

  Domain: 1-167 aa of BC012628

  Sequence: MATSELSCEVSEENCERREAFWAEWKDLTLSTRPEEGCSLHEEDTQRHETYHQQGQCQVLVQRSPWLMMRMGILGRGLQEYQLPYQRVLPLPIFTPAKMGATKEEREDTPIQLQELLALETALGGQCVDRQEVAEITKQLPPVVPVSKPGALRRSLSRSMSQEAQRG

• Full Name: titin-cap (telethonin)
• Calculated Molecular Weight: 167 aa, 19 kDa
• Observed Molecular Weight: 19-21 kDa
• GenBank Accession Number: BC012628
• Gene Symbol: TCAP
• Gene ID (NCBI): 8557
• RRID: AB_3741877
• Conjugate: Unconjugated
• Form: Liquid
• Purification Method: Antigen affinity purification
• UNIPROT ID: O15273
• Storage Buffer: PBS only, pH 7.3.
• Storage Conditions: Store at -80°C.

Background Information

Telethonin, also known as TCAP, is a sarcomeric protein found exclusively in striated and cardiac muscle, where it localizes to the periphery of Z discs that define the border of the sarcomere. It binds to the N-terminus of myoglobin, effectively increasing its mechanical resistance. Mutations in this gene are associated with limb-girdle muscular dystrophy type 2G(PMID: 19679566).