Thyroid Hormone Receptor beta Polyclonal antibody

Thyroid Hormone Receptor beta Polyclonal Antibody for WB, ELISA

Host / Isotype

Rabbit / IgG

Reactivity

Mouse and More (2)

Applications

WB, IF, ELISA

Conjugate

Unconjugated

Publications

1

Cat no : 21007-1-AP

Synonyms

c erbA 2, c erbA beta, ERBA BETA, ERBA2, GRTH, NR1A2, PRTH, THR1, THRB, THRB1, THRB2, Thyroid Hormone Receptor beta

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Validation Data Gallery

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  WB analysis using 21007-1-AP

  Various lysates were subjected to SDS PAGE followed by western blot with 21007-1-AP (Thyroid Hormone Receptor beta antibody) at dilution of 1:3000 incubated at room temperature for 1.5 hours.

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Tested Applications

• Positive WB detected in: mouse retina tissue, mouse eye tissue

Recommended dilution

• Western Blot (WB): WB : 1:1000-1:6000

It is recommended that this reagent should be titrated in each testing system to obtain optimal results.

Sample-dependent, Check data in validation data gallery.

Published Applications

• KD/KO: See 1 publications below
• WB: See 1 publications below
• IF: See 1 publications below

Product Information

21007-1-AP targets Thyroid Hormone Receptor beta in WB, IF, ELISA applications and shows reactivity with Mouse samples.

• Tested Reactivity: Mouse
• Cited Reactivity: human, mouse
• Host / Isotype: Rabbit / IgG
• Class: Polyclonal
• Type: Antibody
• Immunogen: Thyroid Hormone Receptor beta fusion protein Ag15210
• Full Name: thyroid hormone receptor, beta (erythroblastic leukemia viral (v-erb-a) oncogene homolog 2, avian)
• Calculated Molecular Weight: 476 aa, 54 kDa
• Observed Molecular Weight: 50 kDa
• GenBank Accession Number: BC106929
• Gene Symbol: THRB
• Gene ID (NCBI): 7068
• Conjugate: Unconjugated
• Form: Liquid
• Purification Method: Antigen affinity purification
• Storage Buffer: PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
• Storage Conditions: Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20^oC storage. 20ul sizes contain 0.1% BSA.

Background Information

Thyroid hormone receptor beta (THRB), also known as ERBA2, NR1A2, and THR1, belongs to the nuclear hormone receptor family and NR1 subfamily. THRB is a nuclear hormone receptor that can act as a repressor or activator of transcription. Moreover, THRB is also a high-affinity receptor for thyroid hormones, including triiodothyronine and thyroxine. THRB is the most abundant THR isoform in the liver but is also expressed in other tissues and mediates the effects of THs on hepatic carbohydrate and lipid metabolism (PMID: 34884910).

Publications

Species	Application	Title
human,mouse	WB,IF	Theranostics; Palmitoylation of PKCδ by ZDHHC5 in hypothalamic microglia presents as a therapeutic target for fatty liver disease; Authors - Yan-Hang Wang ; KD Validated