Product Information
24345-1-PBS targets UHRF1BP1 in WB, Indirect ELISA applications and shows reactivity with human samples.
| Tested Reactivity | human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen |
CatNo: Ag19677 Product name: Recombinant human UHRF1BP1 protein Source: e coli.-derived, PGEX-4T Tag: GST Domain: 1053-1400 aa of BC137120 Sequence: LGRDRMTSTMHKMLSLPPAKEPMAKTDEGVAAPVSGGAARLRFFSMKRTVSQQSFDGVSLDSSGPEDRISVDSDGSDSFVMLLESESGPESVPPGSLSNVSDNAGVQGSPLVNNYGQGSPAANSSVSPSGEDLIFHPVSVLVLKVNEVSFGIEVRGEDLTVALQAEELTLQQLGTVGLWQFLHGQCPGTCFQESSTLKTGHIRPAVGLRFEVGPGAAVHSPLASQNGFLHLLLHGCDLELLTSVLSGLGPFLEDEEIPVVVPMQIELLNSSITLKDDIPPIYPTSPGPIPITLAMEHVVLKRSDDGVFHIGAAAQDKPSAEVLKSEKRQPPKEQVFLVPTGEVFEQQT Predict reactive species |
| Full Name | UHRF1 binding protein 1 |
| Calculated Molecular Weight | 1440 aa, 159 kDa |
| Observed Molecular Weight | 160-170 kDa |
| GenBank Accession Number | BC137120 |
| Gene Symbol | UHRF1BP1 |
| Gene ID (NCBI) | 54887 |
| RRID | AB_3742108 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification Method | Antigen affinity purification |
| UNIPROT ID | Q6BDS2 |
| Storage Buffer | PBS only, pH 7.3. |
| Storage Conditions | Store at -80°C. |
Background Information
Bridge-like lipid transfer protein family member 3A (BLTP3A), also known as UHRF1BP1, is a conserved protein characterized by six repeating beta-groove modules that form a hydrophobic groove for bulk lipid transfer between membranes. It localizes to VAMP7-positive vesicles and anchors them to LAMP1-positive lysosomes via its chorein domain and Rab7 interaction. Upon lysosomal membrane damage, BLTP3A rapidly dissociates and is re-recruited through its LIR motif binding to mATG8 proteins via the CASM pathway. This dynamic behavior suggests BLTP3A delivers lipids to aid in lysosomal repair (PMID: 40935891). Beyond its cellular function, BLTP3A has been identified as a genetic risk factor for systemic lupus erythematosus.
