Product Information
12964-1-PBS targets UPP2 in IP, Indirect ELISA applications and shows reactivity with human, mouse samples.
| Tested Reactivity | human, mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen |
CatNo: Ag3619 Product name: Recombinant human UPP2 protein Source: e coli.-derived, PGEX-4T Tag: GST Domain: 1-317 aa of BC033529 Sequence: MASVIPASNRSMRSDRNTYVGKRFVHVKNPYLDLMDEDILYHLDLGTKTHNLPAMFGDVKFVCVGGSPNRMKAFALFMHKELGFEEAEEDIKDICAGTDRYCMYKTGPVLAISHGMGIPSISIMLHELIKLLHHARCCDVTIIRIGTSGGIGIAPGTVVITDIAVDSFFKPRFEQVILDNIVTRSTELDKELSEELFNCSKEIPNFPTLVGHTMCTYDFYEGQGRLDGALCSFSREKKLDYLKRAFKAGVRNIEMESTVFAAMCGLCGLKAAVVCVTLLDRLDCDQINLPHDVLVEYQQRPQLLISNFIRRRLGLCD Predict reactive species |
| Full Name | uridine phosphorylase 2 |
| Calculated Molecular Weight | 317 aa, 36 kDa |
| Observed Molecular Weight | 36 kDa |
| GenBank Accession Number | BC033529 |
| Gene Symbol | UPP2 |
| Gene ID (NCBI) | 151531 |
| RRID | AB_3741836 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification Method | Antigen affinity purification |
| UNIPROT ID | O95045 |
| Storage Buffer | PBS only, pH 7.3. |
| Storage Conditions | Store at -80°C. |
Background Information
Uridine phosphorylase (UPP) catalyzes the reversible phosphorolysis of uridine and chemically-related compounds to uracil and ribose-1-phosphate, implicating it in both pyrimidine salvage and regulation of uridine homeostasis .The enzyme is ubiquitously distributed amongst animals and bacteria, with most vertebrates possessing two versions of the phosphorylase, UPP1 and UPP2. While the two human homologues retain ~62% sequence identity, human UPP1 (hUPP1) was the first identified, cloned, and characterized, and consequently has been the focus of the majority of research . Not as much is known about the specific role of human UPP2 (hUPP2). Early studies showed that its tissue distribution was more limited than that of hUPP1, restricted predominantly to the kidneys, with some expression in the liver and spleen . (PMID: 21855639, PMID: 37473754)
