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Anti-Mouse VE-cadherin/CD144 Rabbit Recombinant Antibody, PBS Only (98251-1-PBS)

Anti-Mouse VE-cadherin/CD144 Rabbit Recombinant Antibody, PBS Only

Name: Anti-Mouse VE-cadherin/CD144 Rabbit Recombinant Antibody, PBS Only, 1mg
Brand: Proteintech
SKU: 98251-1-PBS-1MG

VE-cadherin/CD144 Uni-rAb^® Recombinant Antibody for FC

Cat No. 98251-1-PBS

Clone No. 241953D4

Publications (1)

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Host / Isotype

Rabbit / IgG

Reactivity

mouse and More (1)

Applications

IF, FC

Synonyms

VE-cadherin, 241953D4, 7B4, cadherin 5, Cd144

Formulation: PBS Only

PBS, Azide

PBS Only

Conjugate: Unconjugated

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Filter: AllFCAffinity

FC experiment of bEnd.3 using 98251-1-RR (same clone as 98251-1-PBS)
1x10^6 bEnd.3 cells (left) or C2C12 (right) were surface stained with 0.25 ug Anti-Mouse VE-cadherin/CD144 Rabbit Recombinant Antibody (98251-1-RR, Clone: 241953D4) (red) or Rabbit IgG Isotype Control Recombinant Antibody (98136-1-RR, Clone: 240953C9) (blue), and PE-Conjugated Goat Anti-Rabbit IgG(H+L). Cells were not fixed. This data was developed using the same antibody clone with 98251-1-PBS in a different storage buffer formulation.
This validation data has been generated in-house and reviewed by Proteintech scientists. Find out more on our antibody validation policy
×
1x10^6 bEnd.3 cells (left) or C2C12 (right) were surface stained with 0.25 ug Anti-Mouse VE-cadherin/CD144 Rabbit Recombinant Antibody (98251-1-RR, Clone: 241953D4) (red) or Rabbit IgG Isotype Control Recombinant Antibody (98136-1-RR, Clone: 240953C9) (blue), and PE-Conjugated Goat Anti-Rabbit IgG(H+L). Cells were not fixed. This data was developed using the same antibody clone with 98251-1-PBS in a different storage buffer formulation.
Affinity and Kinetic Characterization of 98251-1-RR
Biolayer interferometry (BLl) kinetic assays of 98251-1-RR against Mouse VE-cadherin/CD144 were performed. The affinity constant is 1.65 nM.
This validation data has been generated in-house and reviewed by Proteintech scientists. Find out more on our antibody validation policy

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Overview

Tested Applications
Product Information
Publications (1)

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Product Information

98251-1-PBS targets VE-cadherin/CD144 in IF, FC applications and shows reactivity with mouse samples.

Tested Reactivity	mouse
Cited Reactivity	human
Host / Isotype	Rabbit / IgG
Class	Recombinant
Type	Antibody
Immunogen	CatNo: Eg0921 Product name: Recombinant Mouse VE-cadherin/CD144 protein (His Tag) Source: mammalian cells-derived, pHZ-KIsec-C-6HIS Tag: C-6HIS Domain: 46-592 aa of NM_009868.4 Sequence: DWIWNQMHIDEEKNESLPHYVGKIKSNVNRQNAKYVLQGEFAGKIFGVDANTGNVLAYERLDREKVSEYFLTALIVDKNTNKNLEQPSSFTVKVHDINDNWPVFSHQVFNASVPEMSAIGTSVIRVTAVDADDPTVAGHATVLYQIVKGNEYFSIDNSGLIFTKIKNLDREKQAEYKIVVETQDALGLRGESGTATVMIRLEDINDNFPVFTQSTYTFSVPEDIRVGKPLGFLTVVDPDEPQNRMTKYSIMQGEYRDTFTIETDPKRNEGIIKPTKSLDYEVIQQYTFYIEATDPTIRYEYLSSTSGKNKAMVTINVLDVDEPPVFQRHFYHFKLPENQKKPLIGTVVAKDPDKAQRSIGYSIRKTSDRGQFFRITKQGNIYNEKELDRETYAWYNLTVEANELDSRGNPVGKESIVQVYIEVLDENDNPPEFAQPYEPKVCENAAQGKLVVQISATDKDVVPVNPKFKFALKNEDSNFTLINNHDNTANITVKYGQFNREHAKFHYLPVLISDNGVPSLTGTSTLTVGVCKCNEQGEFTFCEEMAA Predict reactive species
Full Name	cadherin 5
Calculated Molecular Weight	88kDa
GenBank Accession Number	NM_009868.4
Gene Symbol	Cdh5
Gene ID (NCBI)	12562
RRID	AB_3745918
Conjugate	Unconjugated
Form	Liquid
Purification Method	Protein A purification
UNIPROT ID	P55284
Storage Buffer	PBS only, pH 7.3.
Storage Conditions	Store at -80°C.

Background Information

Cadherins are a family of transmembrane glycoproteins that mediate calcium-dependent cell-cell adhesion and play an important role in the maintenance of normal tissue architecture. Vascular endothelial cadherin (VE-cadherin), also known as Cadherin-5 (CDH5) or CD144, is a member of the type II classical cadherin family of cell adhesion proteins (PMID: 21269602). VE-cadherin is expressed specifically in endothelial cells and mediates homophilic adhesion in the vascular endothelium (PMID: 1522121; 8555485; 21269602). VE-cadherin plays a role in the organization of lateral endothelial junctions and in the control of permeability properties of vascular endothelium (PMID: 1522121). VE-cadherin has also been shown to be required for angiogenesis (PMID: 16473763; 18162609).

Publications

What published studies show

The Anti-Mouse VE-cadherin/CD144 Rabbit Recombinant Antibody (241953D4), catalog number 98251-1-PBS, has 1 citation. It appears in Biochemical Pharmacology (2026), in a study examining cipepofol's attenuation of endothelial barrier dysfunction in acute lung injury via DUSP1-dependent MAPK signaling suppression. The research field encompasses vascular endothelial biology, acute lung injury, and MAPK signaling pathways. The antibody was applied in immunofluorescence (IF) on mouse samples.

Species	Application	Title
human	IF	Biochem Pharmacol Cipepofol attenuates endothelial barrier dysfunction in acute lung injury through DUSP1-dependent suppression of MAPK signaling. Authors - Shuting Zhou View Article