Product Information
33831-1-PBS targets WDR12 in WB, Indirect ELISA applications and shows reactivity with human samples.
| Tested Reactivity | human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen |
CatNo: Ag38016 Product name: Recombinant human WDR12 protein Source: e coli.-derived, PGEX-4T Tag: GST Domain: 74-423 aa of BC008082 Sequence: NISSEEVVEIEYVEKYTAPQPEQCMFHDDWISSIKGAEEWILTGSYDKTSRIWSLEGKSIMTIVGHTDVVKDVAWVKKDSLSCLLLSASMDQTILLWEWNVERNKVKALHCCRGHAGSVDSIAVDGSGTKFCSGSWDKMLKIWSTVPTDEEDEMEESTNRPRKKQKTEQLGLTRTPIVTLSGHMEAVSSVLWSDAEEICSASWDHTIRVWDVESGSLKSTLTGNKVFNCISYSPLCKRLASGSTDRHIRLWDPRTKDGSLVSLSLTSHTGWVTSVKWSPTHEQQLISGSLDNIVKLWDTRSCKAPLYDLAAHEDKVLSVDWTDTGLLLSGGADNKLYSYRYSPTTSHVGA Predict reactive species |
| Full Name | WD repeat domain 12 |
| Calculated Molecular Weight | 423 aa, 48 kDa |
| Observed Molecular Weight | 47 kDa |
| GenBank Accession Number | BC008082 |
| Gene Symbol | WDR12 |
| Gene ID (NCBI) | 55759 |
| RRID | AB_3743085 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification Method | Antigen affinity Purification |
| UNIPROT ID | Q9GZL7 |
| Storage Buffer | PBS only, pH 7.3. |
| Storage Conditions | Store at -80°C. |
Background Information
WDR12 is a nucleolar WD-repeat scaffolding protein and an essential component of the PeBoW complex required for 60S ribosomal subunit maturation. By driving pre-rRNA processing, WDR12 supports cell growth and proliferation, while its disruption activates the p53-dependent nucleolar stress pathway. Upregulated in multiple cancers and genetically linked to cardiometabolic traits, WDR12 serves as a central regulator of ribosome biogenesis, cell-cycle control, and cellular homeostasis.
