ZMPSTE24 Recombinant monoclonal antibody, PBS Only

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• ZMPSTE24 Recombinant monoclonal antibody, PBS Only (84547-2-PBS)

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  IF Staining of PC-3 using 84547-2-RR (same clone as 84547-2-PBS)

  Immunofluorescent analysis of (-20°C Ethanol) fixed PC-3 cells using ZMPSTE24 antibody (84547-2-RR, Clone: 241288C3 ) at dilution of 1:500 and CoraLite®488-Conjugated Goat Anti-Rabbit IgG(H+L) (SA00013-2). This data was developed using the same antibody clone with 84547-2-PBS in a different storage buffer formulation.

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  Affinity and Kinetic Characterization of 84547-2-RR

  Biolayer interferometry (BLl) kinetic assays of 84547-2-RR against Human ZMPSTE24 were performed. The affinity constant is below 1 pM.

ZMPSTE24 Uni-rAb^® Recombinant Antibody for IF/ICC, Indirect ELISA

Cat No. 84547-2-PBS

Clone No.241288C3

Host / Isotype

Rabbit / IgG

Reactivity

human

Applications

IF/ICC, Indirect ELISA

Synonyms

FACE-1, FACE1, FACE 1, EC:3.4.24.84, CAAX prenyl protease 1 homolog

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Product Information

84547-2-PBS targets ZMPSTE24 in IF/ICC, Indirect ELISA applications and shows reactivity with human samples.

• Tested Reactivity: human
• Host / Isotype: Rabbit / IgG
• Class: Recombinant
• Type: Antibody
• Immunogen:

  CatNo: Ag33613

  Product name: Recombinant human ZMPSTE24 protein

  Source: e coli.-derived, PET28a

  Tag: 6*His

  Domain: 225-475 aa of BC037283

  Sequence: TPLPEGKLKEEIEVMAKSIDFPLTKVYVVEGSKRSSHSNAYFYGFFKNKRIVLFDTLLEEYSVLNKDIQEDSGMEPRNEEEGNSEEIKAKVKNKKQGCKNEEVLAVLGHELGHWKLGHTVKNIIISQMNSFLCFFLFAVLIGRKELFAAFGFYDSQPTLIGLLIIFQFIFSPYNEVLSFCLTVLSRRFEFQADAFAKKLGKAKDLYSALIKLNKDNLGFPVSDWLFSMWHYSHPPLLERLQALKTMKQH*

• Full Name: zinc metallopeptidase (STE24 homolog, S. cerevisiae)
• Calculated Molecular Weight: 475 aa, 55 kDa
• GenBank Accession Number: BC037283
• Gene Symbol: ZMPSTE24
• Gene ID (NCBI): 10269
• RRID: AB_3672054
• Conjugate: Unconjugated
• Form: Liquid
• Purification Method: Protein A purfication
• UNIPROT ID: O75844
• Storage Buffer: PBS only, pH 7.3.
• Storage Conditions: Store at -80°C.

Background Information

ZMPSTE24(CAAX prenyl protease 1 homolog) gene encodes a zinc metalloproteinase involved in the processing of farnesylated proteins(PubMed: 10373325). The significance of ZMPSTE24 in human disease stems from its role as an enzyme necessary for the correct processing and maturation of lamin A ,an intermediate filament component of the nuclear envelope (PubMed: 16297189).