Validation Data Gallery
Product Information
IL34Cys1 is an unconjugated recombinant anti IL34 Nanobody (VHH). Suitable for for cysteine conjugation with thiol-reactive reagents, e.g. maleimides. Note: unconjugated VHHs are not suited for usage without prior labeling, since they contain reactive Cysteines. Shipment and storage buffers contain TCEP to keep Cysteines reduced.
| Applications | Conjugation |
| Reactivity | Human |
| Conjugate | Unconjugated |
| Type | Nanobody |
| Class | Recombinant |
| Host | Alpaca |
| Affinity | 330 nM |
| Molecular Weight | 15.0 kDa |
| Form | Liquid |
| RRID | AB_3665406 |
| Storage Buffer | 10 mM HEPES pH 7.0, 500 mM NaCl, 0.09% sodium azide |
| Storage Condition | Store at -20°C |
| Shipping | dry ice |
| Background | IL-34 is a 6-α-helix, proinflammatory cytokine that serves as a ligand for colony-stimulating factor-1 receptor (CSF1R). It is expressed most abundantly by spleen cells. It primarily stimulates human peripheral blood monocyte proliferation and macrophage colony formation. It is also required for Langerhans cell and microglia development. IL-34 has been shown to play a protective role in cancer and Alzheimer’s disease, but it can promote the progression of several autoimmune, inflammatory, and metabolic diseases. As such IL-34 could be used as a biomarker to mark the progression of these diseases (PMID: 22579672, 27577879, 31940023). |