Lamin A/C Antibody 21 Publications

Rabbit Polyclonal| Catalog number: 10298-1-AP

  • Print page
  • Download PDF

Be the first to review this product


-_-

Freight/Packing

Con: 67 μg/150 μl

Choose size:

Please visit your regions distributor:


Species specificity:
human, mouse, rat, duck

Positive WB detected in:
NIH/3T3 cells, A375 cells, C6 cells, HEK-293 cells, HeLa cells, mouse heart tissue, mouse ovary tissue, SKOV-3 cells

Positive IP detected in:
A375 cells

Positive IF detected in:
HepG2 cells

Positive FC detected in:
HEK-293T cells

Recommended dilution:
WB : 1:1000-1:6000
IP : 0.5-4.0 ug for IP and 1:500-1:2000 for WB
IF : 1:50-1:500

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.1% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
lamin A/C

Calculated molecular weight:
65 kDa

Observed molecular weight:
65 kDa,70 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
LMNA

Synonyms
70 kDa lamin, CDCD1, CDDC, CMD1A, CMT2B1, EMD2, FPL, FPLD, HGPS, IDC, lamin A, lamin A/C, LDP1, LFP, LGMD1B, LMN1, LMNA, LMNC, Prelamin A/C, PRO1, progerin
Background

Lamin A/C is also named as LMNA, FPL, LFP, EMD2, FPLD, HGPS, LDP1, LMN1. The lamin family of proteins make up the matrix and are highly conserved in evolution. During mitosis, the lamina matrix is reversibly disassembled as the lamin proteins are phosphorylated. Lamin proteins are thought to be involved in nuclear stability, chromatin structure and gene expression. The lack of lamin A/C can be as a novel marker for undifferentiated embryonic stem cells and lamin A/C expression is as an early indicator of differentiation(PMID: 16179429). Mutations in this gene lead to several diseases: Emery-Dreifuss muscular dystrophy, familial partial lipodystrophy, limb girdle muscular dystrophy, dilated cardiomyopathy, Charcot-Marie-Tooth disease, and Hutchinson-Gilford progeria syndrome. This protein has 4 isoforms produced by alternative splicing with the molecular weight of 74 kDa, 65 kDa, 70 kDa and 64 kDa. This antibody can recognize 4 isoforms of Lamin A/C.


Back
to top