Validation Data Gallery
Technical Specifications
| GeneID | 4908 |
| Species | Human |
| Expression | HEK293 |
| Activity(Primary) | 0.2 - 1.5 ug/mL |
| Purity | >95% |
| Endotoxin | <1 EU/µg |
| Accession Number | P20783 |
| Molecular Mass | 14 kDa reduced, 14 kDa non-reduced, monomer, non-glycosylated |
| Formulation | |
| Species Reactivity | human |
Stability and Reconstitution
| Stability and Storage | Product Form | Temperature Conditions | Storage Time (From Date of Receipt) |
|---|---|---|---|
| Lyophilized | -20°C to -80°C | Until Expiry Date | |
| Lyophilized | Room Temperature | 2 weeks | |
| Reconstituted as per CofA | -20°C to -80°C | 6 months | |
| Reconstituted as per CofA | 4°C | 1 week | |
| Avoid repeated freeze-thaw cycles. | |||
| Reconstitution | Briefly centrifuge the vial before opening. It is recommended to reconstitute the protein to 0.2 mg/mL in sterile 1x PBS pH 7.4 containing 0.1% endotoxin-free recombinant human serum albumin (HSA). Gently swirl or tap to mix. |
Background
Human Neurotrophin-3 (NT-3) is a member of the neurotrophin family that also includes NGF, BDNF, and NT-4/5. NT-3 is essential for the development, survival, and differentiation of neurons in the central and peripheral nervous systems. It signals primarily through the TrkC receptor, with lower affinity for TrkA/TrkB, promoting neuronal growth, synaptic plasticity, and survival. NT-3 is widely expressed in neuronal and non-neuronal tissues during development and adulthood, and plays a key trophic role in neuronal circuit formation, proprioception, and long-term neural maintenance.
Synonyms
NT3, HDNF, NGF2, NTF3, NGF-2