GRK2 Antibody 3 Publications

Rabbit Polyclonal| Catalog number: 13990-1-AP

Featured Product KD/KO validated

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Freight/Packing

Con: 98 μg/150 μl

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Species specificity:
human

Positive WB detected in:
Jurkat cells, HL-60 cells

Positive IP detected in:
HL-60 cells

Positive IHC detected in:
human lymphoma tissue

Positive FC detected in:
HeLa cells

Recommended dilution:
WB : 1:500-1:2000
IP : 0.5-4.0 ug for IP and 1:500-1:2000 for WB
IHC : 1:20-1:200

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
adrenergic, beta, receptor kinase 1

Calculated molecular weight:
689aa,80 kDa

Observed molecular weight:
80 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
ADRBK1

Synonyms
ADRBK1, BARK, BARK1, Beta ARK 1, BETA ARK1, FLJ16718, GRK2
Background

GRK2 (G-protein coupled receptor kinase 2) is also named as ADRBK1 (Beta-adrenergic receptor kinase 1), BARK, and BARK1. G-protein-coupled receptors (GPCRs) transmit extracellular signals across the cell membrane. GPCR kinases (GRKs) desensitize GPCR signals in the cell membrane. GRK2 translocation from the cytoplasm to the cell membrane in response to extracellular signals is critical to the function of the protein, where GRK phosphorylation is an important component of its translocation to the membrane.(PMID:27412951)


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