CD22 Antibody 0 Publications

Mouse Monoclonal| Catalog number: 66103-1-Ig |CloneNo.: 7A2F1

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Freight/Packing

Con: 328 μg/150 μl

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Species specificity:
human

Positive WB detected in:
Ramos cells

Positive IHC detected in:
human tonsillitis tissue, human lymphoma tissue, human tonsillitis tissue

Recommended dilution:
WB : 1:2500-1:10000
IHC : 1:100-1:800

Product Information


Source:
Mouse

Purification method:
Protein A purification

Isotype:
IgG2a

Storage:
PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
CD22 molecule

Calculated molecular weight:
847aa,95 kDa

Observed molecular weight:
135 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
CD22

Synonyms
B cell receptor CD22, BL CAM, CD22, CD22 molecule, FLJ22814, SIGLEC 2, SIGLEC2, T cell surface antigen Leu 14
Background

CD22, also known as Siglec-2 (sialic acid binding Ig-like lectin 2) or BL-CAM (B-lymphocyte cell adhesion molecule), is a 130-140 kDa, B-cell restricted, type I transmembrane glycoprotein belonging to the immunoglobulin gene superfamily. The expression of CD22 is developmentally regulated. It is expressed at low levels in the cytoplasm of pro-B and pre-B cells and present on the cell surface only at mature stages of B-cell differentiation. Cell surface expression is lost during terminal differentiation into plasma cell and after B-cell activation. CD22 is an inhibitory receptor for B-cell receptor (BCR) signalling, preferentially binds to alpha-2,6-linked sialic acid and mediates B-cell B-cell interactions. It plays a crucial role in activation and differentiation of the B-cell.


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