|Positive WB detected in||Human heart, tissue|
|Positive IHC detected in||human heart tissue, human hysteromyoma tissue, human skeletal muscle tissue|
Note: suggested antigen retrieval with TE buffer pH 9.0; (*) Alternatively, antigen retrieval may be performed with citrate buffer pH 6.0
|Western Blot (WB)||WB : 1:500-1:2000|
|Immunohistochemistry (IHC)||IHC : 1:50-1:200|
|Sample-dependent, check data in validation data gallery|
The 60226-1-Ig immunogen is Fusion Protein Desmin protein expressed in E. coli.
|Cited Species||human, mouse, rat|
|Host / Isotype||Mouse / IgG2a|
|Immunogen||Desmin fusion protein Ag9675|
|Calculated molecular weight||470aa,54 kDa|
|Observed molecular weight||55 kDa|
|GenBank accession number||BC032116|
|Gene ID (NCBI)||1674|
|Purification Method||Protein A purification|
|Storage Buffer||PBS with 0.02% sodium azide and 50% glycerol pH 7.3.|
|Storage Conditions||Store at -20oC. Aliquoting is unnecessary for -20oC storage.|
Desmin is the main intermediate filament protein in skeletal and cardiac muscle cells and is essential for both the structural integrity and the survival of muscle cells. As an abundant muscle-specific protein, desmin has been widely used as a marker of muscle derived tumors. Anti-desmin is also valuable in the differential diagnosis of tumors of uncertain origin.
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