Validation Data Gallery
|Sample-dependent, check data in validation data gallery|
10686-1-AP targets AGO2 in WB, RIP, IP, CLIP,ELISA applications and shows reactivity with human, mouse, rat samples.
|Tested Reactivity||human, mouse, rat|
|Cited Reactivity||fish, human, mouse|
|Host / Isotype||Rabbit / IgG|
|Immunogen||AGO2 fusion protein Ag1032|
|Full Name||eukaryotic translation initiation factor 2C, 2|
|Calculated molecular weight||97 kDa|
|GenBank accession number||BC007633|
|Gene ID (NCBI)||27161|
|Purification Method||Antigen affinity purification|
|Storage Buffer||PBS with 0.02% sodium azide and 50% glycerol pH 7.3.|
|Storage Conditions||Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage.|
EIF2C2, also named as AGO2, belongs to the argonaute family and Ago subfamily. It is required for RNA-mediated gene silencing (RNAi) by the RNA-induced silencing complex (RISC). The 'minimal RISC' appears to include EIF2C2/AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). EIF2C2 may inhibit translation initiation by binding to the 7-methylguanosine cap, thereby preventing the recruitment of the translation initiation factor eIF4-E. It also inhibit translation initiation via interaction with EIF6, which itself binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit. EIF2C2 can also upregulate the translation of specific mRNAs under certain growth conditions. This antibody is specific to EIF2C2. EIF2C2 exists two isoforms and molecular weight of isoforms are 97 kDa and 94 kDa.
A GBM-like V-ATPase signature directs cell-cell tumor signaling and reprogramming via large oncosomes.
CFTR mutation compromises spermatogenesis by enhancing miR-15b maturation and suppressing its regulatory target CDC25A.
Am J Transl Res
LINC00261 functions as a competing endogenous RNA to regulate BCL2L11 expression by sponging miR-132-3p in endometriosis.
Biochim Biophys Acta
Global analysis of AGO2-bound RNAs reveals that miRNAs induce cleavage of target RNAs with limited complementarity.
Biochim Biophys Acta
MicroRNAs of miR-17-92 cluster increase gene expression by targeting mRNA-destabilization pathways.
J Exp Clin Cancer Res
Long non-coding RNA LPP-AS2 promotes glioma tumorigenesis via miR-7-5p/EGFR/PI3K/AKT/c-MYC feedback loop.