FUS/TLS Antibody 37 Publications

Rabbit Polyclonal| Catalog number: 11570-1-AP

Featured Product KD/KO validated

  • Print page
  • Download PDF

Be the first to review this product


-_-

Freight/Packing

Con: 74 μg/150 μl

Choose size:

Please visit your regions distributor:


Species specificity:
human, mouse, rat

Positive WB detected in:
HEK-293 cells,SMMC-7721 cells, HepG2 cells, K-562 cells, HeLa cells, human kidney tissue, HL-60 cells, Jurkat cells, mouse brain tissue

Positive IP detected in:
K-562 cells

Positive IHC detected in:
human breast cancer tissue,human brain tissue, human ovary tumor tissue

Positive IF detected in:
HepG2 cells

Positive FC detected in:
HeLa cells

ApplicationNote:
For IHC detection, 60160-1-Ig (mAB) is better.

Recommended dilution:
WB : 1:1000-1:4000
IP : 0.5-4.0 ug for IP and 1:500-1:2000 for WB
IHC : 1:50-1:500
IF : 1:50-1:500

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.1% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
fusion (involved in t(12;16) in malignant liposarcoma)

Calculated molecular weight:
75 kDa

Observed molecular weight:
68-75 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
FUS

Synonyms
75 kDa DNA pairing protein, FUS, FUS1, FUS-CHOP, hnRNP P2, Oncogene FUS, Oncogene TLS, POMp75, RNA binding protein FUS, TLS, TLS/CHOP
Background

FUS (also named TLS and POMp75) belongs to the RRM TET family. FUS may play a role in the maintenance of genomic integrity; it binds both single-stranded and double-stranded DNA and promotes ATP-independent annealing of complementary single-stranded DNAs and D-loop formation in superhelical double-stranded DNA. FUS is also an RNA-binding protein, and its links to neurodegenerative disease proffer the intriguing possibility that altered RNA metabolism or RNA processing may underlie or contribute to neuron degeneration[PMID: 22640227]. FUS may be a cause of angiomatoid fibrous histiocytoma (AFH) and is implicated in certain forms of amyotrophic lateral sclerosis (ALS) and frontotemporal dementias (FTDs) such as frontotemporal lobar dementia with ubiquitin inclusions (FTLD-U)[PMID: 22640227]. This antibody is a rabbit polyclonal antibody raised against an internal region of human FUS.


Back
to top