- Featured Product
- KD/KO Validated
GSNOR,ADH5 Polyclonal antibody
GSNOR,ADH5 Polyclonal Antibody for IF, IHC, WB,ELISA
Cat no : 11051-1-AP
|Positive WB detected in||mouse kidney tissue, human brain tissue, human heart tissue, mouse brain tissue, mouse liver tissue, human liver tissue|
|Positive IHC detected in||human prostate cancer tissue|
Note: suggested antigen retrieval with TE buffer pH 9.0; (*) Alternatively, antigen retrieval may be performed with citrate buffer pH 6.0
|Positive IF detected in||HepG2 cells|
|Western Blot (WB)||WB : 1:500-1:1000|
|Immunohistochemistry (IHC)||IHC : 1:50-1:500|
|Immunofluorescence (IF)||IF : 1:50-1:500|
|Sample-dependent, check data in validation data gallery|
11051-1-AP targets GSNOR,ADH5 in WB, IP, IHC, IF,ELISA applications and shows reactivity with human, mouse, rat samples.
|Tested Reactivity||human, mouse, rat|
|Cited Reactivity||chicken, human, mouse, pig, rat|
|Host / Isotype||Rabbit / IgG|
|Immunogen||GSNOR,ADH5 fusion protein Ag1533|
|Full Name||alcohol dehydrogenase 5 (class III), chi polypeptide|
|Calculated molecular weight||40 kDa|
|Observed molecular weight||40 kDa|
|GenBank accession number||BC070491|
|Gene ID (NCBI)||128|
|Purification Method||Antigen affinity purification|
|Storage Buffer||PBS with 0.02% sodium azide and 50% glycerol pH 7.3.|
|Storage Conditions||Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage.|
ADH5, also named as ADHX, FDH FALDH GSH-FDH ADH3 and GSNOR, belongs to the zinc-containing alcohol dehydrogenase family and Class-III subfamily. It is remarkably ineffective in oxidizing ethanol, but it readily catalyzes the oxidation of long-chain primary alcohols and the oxidation of S-(hydroxymethyl) glutathione. ADH5 mediates multiple cardiovascular functions. It plays in regulating heterocellular communication in the artery wall. (PMID:21071693). ADH5 immunostaining is distributed in both the nucleus and cytoplasm of the retinal ganglion cells(PMID:22117533).
Int J Impot Res
S-nitrosylation of endothelial nitric oxide synthase impacts erectile function.
J Pharmacol Sci
Increased nitrosoglutathione reductase activity in hypoxic pulmonary hypertension in mice.
Copper disrupts S-nitrosothiol signaling in activated BV2 microglia.
Treatment with a highly selective β? antagonist causes dose-dependent impairment of cerebral perfusion after hemodilution in rats.
Am J Physiol Cell Physiol
Balance between S-nitrosylation and denitrosylation modulates myoblast proliferation independently of soluble guanylyl cyclase activation.
Invest Ophthalmol Vis Sci
S-Nitrosoglutathione inhibits inducible nitric oxide synthase upregulation by redox post-translational modification in experimental diabetic retinopathy.