MAP1B Antibody 3 Publications

Rabbit Polyclonal| Catalog number: 21633-1-AP

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Freight/Packing

Con: 27 μg/150 μl

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Species specificity:
human, mouse

Positive WB detected in:
mouse cerebellum tissue, human brain tissue

Positive IHC detected in:
mouse brain tissue

Positive IF detected in:
SH-SY5Y cells, mouse brain tissue

Positive FC detected in:
SH-SY5Y cells

Recommended dilution:
WB : 1:500-1:1000
IHC : 1:20-1:200
IF : 1:10-1:100

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.1% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
microtubule-associated protein 1B

Calculated molecular weight:
2468aa,271 kDa

Observed molecular weight:
320 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
MAP1B

Synonyms
MAP 1B, MAP1B, MAP5
Background

Microtubule-associated protein 1B (MAP1B) is a cytoskeleton protein which can promote microtubule assembly. Previous reports have suggested that this protein is closely involved in neuronal development based on its extensive expression in the developing brain and moderate in mature neurons. Gene disruption or knockout studies of the MAP1B gene led to a delayed development of the nervous system in mice. It includes the N-terminal heavy chain and a C-terminal light chain. The MAP1B heavy chain has a microtubule-stabilization effect, and contains an actin-binding site that may play a role in the crosslinking of actin and microtubules, a function that may be important in neurite elongation. Various isoforms around 300-350 kDa of MAP1B can be observed due to the differences in phosphorylation state. (10704485)


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