PAX8 Antibody 209 Publications

Rabbit Polyclonal| Catalog number: 10336-1-AP

Featured Product KD/KO validated

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Freight/Packing

Con: 35 μg/150 μl

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Species specificity:
human, mouse, rat, bovine, zebrafish

Positive WB detected in:
SKOV-3 cells, Raji cells, NIH/3T3 cells, HEK-293 cells

Positive IP detected in:
HeLa cells, SKOV-3 cells

Positive IHC detected in:
human ovary tumor tissue, human thyroid cancer tissue, rat kidney tissue, human testis tissue, human renal cell carcinoma tissue, mouse kidney tissue

Positive IF detected in:
SKOV-3 cells

Positive FC detected in:
HeLa cells

Recommended dilution:
WB : 1:500-1:2000
IP : 0.5-4.0 ug for IP and 1:500-1:2000 for WB
IHC : 1:200-1:1200
IF : 1:50-1:200

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.1% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
paired box 8

Calculated molecular weight:
48 kDa

Observed molecular weight:
48 kDa, 58 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
PAX8

Synonyms
paired box 8, Paired box protein Pax 8, PAX8
Background

PAX8 is a member of the paired box (PAX) family of transcription factors, typically containing a paired box domain and a paired-type homeodomain. It is expressed during organogenesis of the thyroid gland, kidney and Mullerian system. It is thought to regulate the expression of Wilms tumor suppressor (WT1) gene and mutations in PAX8 have been associated with Wilms tumor cells, thyroid and ovarian carcinomas. PAX8 is a useful marker in distinguishing ovarian carcinomas from mammary carcinomas (PMID: 18724243). PAX8 is expressed in a high percentage of ovarian serous, endometrioid, and clear cell carcinomas, but only rarely in primary ovarian mucinous adenocarcinomas.

PAX8 has 5 isoforms with calculated MW 31 kDa, 34 kDa, 41 kDa, 43 kDa and 48 kDa. And there is a 58-60 kDa band corresponding to the electrophoretic mobility of PAX8 (PMID:15650356). Proteintech’s 10336-1-AP antibody has cross-reactivities with the other PAX family members.


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