CD31 Antibody 3 Publications

Mouse Monoclonal| Catalog number: 66065-1-Ig |CloneNo.: 2A1E2

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Freight/Packing

Con: 137 μg/150 μl

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Species specificity:
human

Positive WB detected in:
Jurkat cells

Positive IHC detected in:
human tonsillitis tissue

Positive IF detected in:
human tonsillitis tissue

Recommended dilution:
WB : 1:500-1:2000
IHC : 1:200-1:800
IF : 1:50-1:500

Product Information


Source:
Mouse

Purification method:
Protein A purification

Isotype:
IgG2b

Storage:
PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
platelet/endothelial cell adhesion molecule

Calculated molecular weight:
83 kDa

Observed molecular weight:
120 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
PECAM1

Synonyms
CD31, EndoCAM, FLJ58394, GPIIA, PECA1, PECAM 1, PECAM1, VEC marker
Background

Platelet endothelial cell adhesion molecule-1 (PECAM-1, CD31) is a member of the immunoglobulin gene superfamily of cell adhesion molecules. CD31 is a transmembrane glycoprotein with a molecular mass of approximately 120-140 kDa. It is highly expressed on the surface of the endothelium, making up a large portion of its intracellular junctions. PECAM-1 is also present on the surface of hematopoietic cells and immune cells including platelets, monocytes, neutrophils, natural killer cells, megakaryocytes and some types of T-cell (PMID: 9011572). As well as its role in cell-cell adhesion, PECAM-1 functions as a signaling receptor, and is involved in important physiological events such as nitric oxide production, regulation of T-cell immunity and tolerance, leukocyte transendothelial migration and inflammation and angiogenesis (PMID: 21183735; 20978210; 17872453; 20634489).


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