ROCK1 Antibody 13 Publications

Rabbit Polyclonal| Catalog number: 21850-1-AP

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Freight/Packing

Con: 53 μg/150 μl

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Species specificity:
human, mouse, rat

Positive WB detected in:
HepG2 cells, A431 cells, HeLa cells, Jurkat cells, mouse spleen tissue, NIH/3T3 cells

Positive IHC detected in:
human lung cancer tissue, human lung cancer tissue, human tonsillitis tissue

Positive IF detected in:
HepG2 cells

Recommended dilution:
WB : 1:500-1:3000
IHC : 1:20-1:200
IF : 1:50-1:500

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
Rho-associated, coiled-coil containing protein kinase 1

Calculated molecular weight:
1354aa,158 kDa

Observed molecular weight:
150-160 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
ROCK1

Synonyms
p160 ROCK 1, P160ROCK, PRO0435, ROCK1
Background

ROCK1, also named as p160ROCK and NY-REN-35, belongs to the protein kinase superfamily and AGC Ser/Thr protein kinase family. ROCK1 phosphorylates and activates DAPK3, which then regulates myosin light chain phosphatase through phosphorylation of MYPT1 thereby regulating the assembly of the actin cytoskeleton, cell migration, invasiveness of tumor cells, smooth muscle contraction and neurite outgrowth. ROCK1 is required for centromere positioning and centromere-dependent exit from mitosis. It is necessary for apoptotic membrane blebbing. ROCK1 catalyzes the reaction: ATP + a protein = ADP + a phosphoprotein.


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