STAT3 Antibody 2 Publications

Mouse Monoclonal| Catalog number: 60199-1-Ig |CloneNo.: 3G2D12

Featured Product KD/KO validated

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Freight/Packing

Con: 164 μg/150 μl

Choose size:

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Species specificity:
human, mouse, rat

Positive WB detected in:
HeLa cells, HeLa

Positive IP detected in:
HeLa cells

Positive IHC detected in:
human cervical cancer tissue, human heart tissue, human breast cancer tissue, human endometrial cancer tissue, human liver tissue, human lung cancer tissue

Positive IF detected in:
HepG2 cells

Recommended dilution:
WB : 1:2000-1:20000
IP : 0.5-4.0 ug for IP and 1:1000-1:4000 for WB
IHC : 1:50-1:500
IF : 1:50-1:500

Product Information


Source:
Mouse

Purification method:
Protein A purification

Isotype:
IgG2a

Storage:
PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
signal transducer and activator of transcription 3 (acute-phase response factor)

Calculated molecular weight:
770aa,88 kDa

Observed molecular weight:
88 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
STAT3

Synonyms
Acute phase response factor, APRF, FLJ20882, HIES, STAT3
Background

Signal transducer and activator of transcription 3 (acute-phase response factor) (STAT3, synonyms: APRF, FLJ20882, MGC16063) is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. STAT3 is activated through phosphorylation in response to various cytokines and growth factors including IFNs, EGF, IL5, IL6, HGF, LIF and BMP2. STAT3 mediates the expression of a variety of genes in response to cell stimuli, and thus plays a key role in many cellular processes such as cell growth and apoptosis. The small GTPase Rac1 has been shown to bind and regulate the activity of STAT3. This antibody is a mouse monoclonal antibody raised against residues near the N terminus of human STAT3. STAT3 exists three isoforms and the molecular weight of each isoform respectively is 83 kDa, 87 kDa and 88 kDa.


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