Anticorps Monoclonal anti-CD223

CD223 Monoclonal Antibody for FC

Hôte / Isotype

Rat / IgG1, kappa

Réactivité testée

souris

Applications

FC

Conjugaison

CoraLite® Plus 647 Fluorescent Dye

CloneNo.

C9B7W

N° de cat : CL647-65098

Synonymes

CD223, LAG 3, Lag3, Ly66, lymphocyte activation gene 3



Applications testées

Résultats positifs en cytométrieCon-A stimulated BALB/c mouse splenocytes,

Dilution recommandée

ApplicationDilution
This reagent has been tested for flow cytometric analysis. It is recommended that this reagent should be titrated in each testing system to obtain optimal results.
Sample-dependent, check data in validation data gallery

Informations sur le produit

CL647-65098 cible CD223 dans les applications de FC et montre une réactivité avec des échantillons souris

Réactivité souris
Hôte / Isotype Rat / IgG1, kappa
Clonalité Monoclonal
Type Anticorps
Immunogène Protéine de fusion CD223-Ig murine
Nom complet lymphocyte-activation gene 3
Numéro d’acquisition GenBankBC120591
Symbole du gène Lag3
Identification du gène (NCBI) 16768
Conjugaison CoraLite® Plus 647 Fluorescent Dye
Excitation/Emission maxima wavelengths654 nm / 674 nm
Forme Liquide
Méthode de purification Purification par affinité
Tampon de stockage PBS with 0.09% sodium azide.
Conditions de stockageStore at 2-8°C. Avoid exposure to light. Stable for one year after shipment.

Informations générales

Lymphocyte activation gene 3 protein (LAG-3), also known as CD223, is a type I transmembrane protein belonging to the immunoglobulin superfamily (PMID: 1692078). It is a CD4-related molecule that binds MHC class II with high affinity (PMID: 1692078; 9159144). LAG-3 is expressed on activated T and NK cells. Besides, natural CD4(+)CD25(+) Tregs express LAG-3 upon activation (PMID: 15485628). LAG-3 negatively regulates T-cell function and homeostasis, and contributes to the suppressor activity of Tregs (PMID: 14644131; 15485628).

Protocole

Product Specific Protocols
FC protocol for CL Plus 647 CD223 antibody CL647-65098Download protocol
Standard Protocols
Click here to view our Standard Protocols