Anticorps Polyclonal de lapin anti-TLR2

• Phare
• Validé par KD/KO

TLR2 Polyclonal Antibody for IHC, ELISA

Hôte / Isotype

Lapin / IgG

Réactivité testée

Humain, rat, souris et plus (1)

Applications

WB, IP, IHC, IF, ELISA

Conjugaison

Non conjugué

Publications

24

N° de cat : 17236-1-AP

Synonymes

CD282, TIL4, TLR2, toll like receptor 2

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Galerie de données de validation

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  IHC staining of human tonsillitis using 17236-1-AP

  Immunohistochemical analysis of paraffin-embedded human tonsillitis tissue slide using 17236-1-AP (TLR2 antibody) at dilution of 1:400 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0).

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  IHC staining of human tonsillitis using 17236-1-AP

  Immunohistochemical analysis of paraffin-embedded human tonsillitis tissue slide using 17236-1-AP (TLR2 antibody) at dilution of 1:400 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0).

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Applications testées

• Résultats positifs en IHC: tissu d'amygdalite humain, ; il est suggéré de démasquer l'antigène avec un tampon de TE buffer pH 9.0; (*) À défaut, 'le démasquage de l'antigène peut être 'effectué avec un tampon citrate pH 6,0.

Dilution recommandée

• Immunohistochimie (IHC): IHC : 1:200-1:800

It is recommended that this reagent should be titrated in each testing system to obtain optimal results.

Sample-dependent, check data in validation data gallery

Applications publiées

• KD/KO: See 3 publications below
• WB: See 15 publications below
• IHC: See 6 publications below
• IF: See 1 publications below
• IP: See 1 publications below

Informations sur le produit

17236-1-AP cible TLR2 dans les applications de WB, IP, IHC, IF, ELISA et montre une réactivité avec des échantillons Humain, rat, souris

• Réactivité: Humain, rat, souris
• Réactivité citée: rat, Humain, porc, souris
• Hôte / Isotype: Lapin / IgG
• Clonalité: Polyclonal
• Type: Anticorps
• Immunogène: TLR2 Protéine recombinante Ag11079
• Nom complet: toll-like receptor 2
• Masse moléculaire calculée: 784 aa, 90 kDa
• Numéro d’acquisition GenBank: BC033756
• Symbole du gène: TLR2
• Identification du gène (NCBI): 7097
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Purification par affinité contre l'antigène
• Tampon de stockage: PBS avec azoture de sodium à 0,02 % et glycérol à 50 % pH 7,3
• Conditions de stockage: Stocker à -20°C. Stable pendant un an après l'expédition. L'aliquotage n'est pas nécessaire pour le stockage à -20^oC Les 20ul contiennent 0,1% de BSA.

Informations générales

TLR2, also known as CD282, is a member of the Toll-like receptor (TLR) family. TLR receptors are type I integral transmembrane glycoproteins that play a fundamental role in pathogen recognition and activation of innate immunity. TLR2 is expressed by immune cells including monocytes/macrophages, polymorphonuclear leukocytes (PMLs), and dendritic cells, and is also expressed by some no-immune cells including endothelial and epithelial cells (PMID: 21428911; 22566960). TLR2 forms heterodimers with TLR1 and TLR6, which is the initial step in a cascade of events leading to significant innate immune responses, development of adaptive immunity to pathogens, and protection from immune sequelae related to infection with these pathogens (PMID: 22566960).

Publications

Species	Application	Title
rat	WB	Mater Today Bio; Intracellular hydrogelation of macrophage conjugated probiotics for hitchhiking delivery and combined treatment of colitis; Authors - Jingzhe Wang
human	WB	Mol Cancer; The regulation of toll-like receptor 2 by miR-143 suppresses the invasion and migration of a subset of human colorectal carcinoma cells.; Authors - Guo Haiyan H ; KD Validated
human		Bioorg Chem; Synthesis, evaluation and molecular dynamics study of human toll-like receptor 2/6 specific monoacyl lipopeptides as candidate immunostimulants; Authors - Yueyue Zhu
human	WB	Eur J Nutr; Oral intake of xanthohumol attenuates lipoteichoic acid-induced inflammatory response in human PBMCs.; Authors - Finn Jung
human	WB	Front Pharmacol; A Series of Genes for Predicting Responses to Anti-Tumor Necrosis Factor α Therapy in Crohn's Disease.; Authors - Kai Nie ; KD Validated
human	WB	Front Mol Biosci; Development and Validation of a 7-Gene Inflammatory Signature Forecasts Prognosis and Diverse Immune Landscape in Lung Adenocarcinoma.; Authors - Aitao Nai

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