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- KD/KO Validated
TLR2 Monoclonal antibody, PBS Only
TLR2 Monoclonal Antibody for WB, IF, IHC, Indirect ELISA
Host / Isotype
Mouse / IgG2a
Reactivity
Human
Applications
WB, IF, IHC, Indirect ELISA
Conjugate
Unconjugated
CloneNo.
1C1D3
Cat no : 66645-1-PBS
Synonyms
Validation Data Gallery
Recommended dilution
Application | Dilution |
---|---|
It is recommended that this reagent should be titrated in each testing system to obtain optimal results. | |
Sample-dependent, Check data in validation data gallery. |
Product Information
66645-1-PBS targets TLR2 in WB, IF, IHC, Indirect ELISA applications and shows reactivity with Human samples.
Tested Reactivity | Human |
Host / Isotype | Mouse / IgG2a |
Class | Monoclonal |
Type | Antibody |
Immunogen | TLR2 fusion protein Ag25626 |
Full Name | toll-like receptor 2 |
Calculated Molecular Weight | 784 aa, 90 kDa |
Observed Molecular Weight | 90-100 kDa |
GenBank Accession Number | BC033756 |
Gene Symbol | TLR2 |
Gene ID (NCBI) | 7097 |
Conjugate | Unconjugated |
Form | Liquid |
Purification Method | Protein A purification |
Storage Buffer | PBS Only |
Storage Conditions | Store at -80°C. |
Background Information
TLR2, also known as CD282, is a member of the Toll-like receptor (TLR) family. TLR receptors are type I integral transmembrane glycoproteins which play a fundamental role in pathogen recognition and activation of innate immunity. TLR2 is expressed by immune cells including monocytes/macrophages, polymorphonuclear leukocytes (PMLs) and dendritic cells, and is also expressed by some no-immune cells including endothelial and epithelial cells (PMID: 21428911; 22566960). TLR2 forms heterodimers with TLR1 and TLR6, which is the initial step in a cascade of events leading to significant innate immune responses, development of adaptive immunity to pathogens and protection from immune sequelae related to infection with these pathogens (PMID: 22566960).