ABR Polyclonal antibody, PBS Only

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• ABR Polyclonal antibody, PBS Only (29350-1-PBS)

• 

  WB analysis using 29350-1-AP (same clone as 29350-1-PBS)

  Various lysates were subjected to SDS PAGE followed by western blot with 29350-1-AP (ABR antibody) at dilution of 1:2000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 29350-1-PBS in a different storage buffer formulation.

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  WB analysis of U-251 using 29350-1-AP (same clone as 29350-1-PBS)

  WB result of ABR antibody (29350-1-AP; 1:2000; incubated at room temperature for 1.5 hours) with sh-Control and sh-ABR transfected U-251 cells. This data was developed using the same antibody clone with 29350-1-PBS in a different storage buffer formulation.

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  IHC staining of rat brain using 29350-1-AP (same clone as 29350-1-PBS)

  Immunohistochemical analysis of paraffin-embedded rat brain tissue slide using 29350-1-AP (ABR antibody) at dilution of 1:1000 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 29350-1-PBS in a different storage buffer formulation.

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  IHC staining of rat brain using 29350-1-AP (same clone as 29350-1-PBS)

  Immunohistochemical analysis of paraffin-embedded rat brain tissue slide using 29350-1-AP (ABR antibody) at dilution of 1:1000 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 29350-1-PBS in a different storage buffer formulation.

• Featured Product
• KD/KO Validated

ABR Polyclonal Antibody for WB, IHC, Indirect ELISA

Cat No. 29350-1-PBS

Host / Isotype

Rabbit / IgG

Reactivity

human, mouse, rat

Applications

WB, IHC, Indirect ELISA

Synonyms

active BCR related gene, MDB

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Product Information

29350-1-PBS targets ABR in WB, IHC, Indirect ELISA applications and shows reactivity with human, mouse, rat samples.

• Tested Reactivity: human, mouse, rat
• Host / Isotype: Rabbit / IgG
• Class: Polyclonal
• Type: Antibody
• Immunogen:

  CatNo: Ag29522

  Product name: Recombinant human ABR protein

  Source: e coli.-derived, PGEX-4T

  Tag: GST

  Domain: 1-87 aa of NM_021962

  Sequence: MEPLSHRGLPRLSWIDTLYSNFSYGTDEYDGEGNEEQKGPPEGSETMPYIDESPTMSPQLSARSQGGGDGVSPTPPEGLAPGVEAGK

• Full Name: active BCR-related gene
• Calculated Molecular Weight: 98 kDa
• Observed Molecular Weight: 97-100 kDa
• GenBank Accession Number: NM_021962
• Gene Symbol: ABR
• Gene ID (NCBI): 29
• RRID: AB_3086122
• Conjugate: Unconjugated
• Form: Liquid
• Purification Method: Antigen affinity purification
• UNIPROT ID: Q12979
• Storage Buffer: PBS only, pH 7.3.
• Storage Conditions: Store at -80°C.

Background Information

ABR (Active breakpoint cluster region-related protein) is the only protein known in humans and mice to share high homology with BCR (68% amino acid identity). BCR(Breakpoint cluster region) gene was originally identified due to its involvement in a specific chromosomal translocation that causes the development of chronic myeloid leukemia and a subset of acute lymphoblastic leukemia. The C-terminus is a GTPase-activating protein domain which stimulates GTP hydrolysis by RAC1, RAC2 and CDC42. (PMID: 17116687, PMID: 37507586)