APH1A Recombinant monoclonal antibody, PBS Only

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• APH1A Recombinant monoclonal antibody, PBS Only (87181-1-PBS)

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  WB analysis using 87181-1-RR (same clone as 87181-1-PBS)

  U-937 cells were subjected to SDS PAGE followed by western blot with 87181-1-RR (APH1A antibody) at dilution of 1:5000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 87181-1-PBS in a different storage buffer formulation.

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  IF Staining of U-937 using 87181-1-RR (same clone as 87181-1-PBS)

  Immunofluorescent analysis of (4% PFA) fixed U-937 cells using APH1A antibody (87181-1-RR, Clone: 251353F8 ) at dilution of 1:200 and CoraLite®488-Conjugated Goat Anti-Rabbit IgG(H+L) (SA00013-2). This data was developed using the same antibody clone with 87181-1-PBS in a different storage buffer formulation.

APH1A Uni-rAb^® Recombinant Antibody for WB, IF/ICC, Indirect ELISA

Cat No. 87181-1-PBS

Clone No.251353F8

Host / Isotype

Rabbit / IgG

Reactivity

human

Applications

WB, IF/ICC, Indirect ELISA

Synonyms

APH 1A, Aph 1alpha, APH-1a, Aph-1alpha, CGI 78

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Product Information

87181-1-PBS targets APH1A in WB, IF/ICC, Indirect ELISA applications and shows reactivity with human samples.

• Tested Reactivity: human
• Host / Isotype: Rabbit / IgG
• Class: Recombinant
• Type: Antibody
• Immunogen:

  Peptide

• Full Name: anterior pharynx defective 1 homolog A (C. elegans)
• Calculated Molecular Weight: 265 aa, 29 kDa
• Observed Molecular Weight: 21 kDa
• GenBank Accession Number: BC015568
• Gene Symbol: APH1A
• Gene ID (NCBI): 51107
• RRID: AB_3745395
• Conjugate: Unconjugated
• Form: Liquid
• Purification Method: Protein A purification
• UNIPROT ID: Q96BI3
• Storage Buffer: PBS only, pH 7.3.
• Storage Conditions: Store at -80°C.

Background Information

APH1A is a component of the gamma secretase complex that cleaves integral membrane proteins such as Notch receptors and beta-amyloid precursor protein. The gamma secretase complex contains this gene product, or the paralogous anterior pharynx defective 1 homolog B (APH1B), along with the presenilin, nicastrin, and presenilin enhancer-2 proteins. The precise function of this seven-transmembrane-domain protein is unknown though it is suspected of facilitating the association of nicastrin and presenilin in the gamma secretase complex as well as interacting with substrates of the gamma secretase complex prior to their proteolytic processing. Polymorphisms in a promoter region of this gene have been associated with an increased risk for developing sporadic Alzheimer's disease.