CoraLite® Plus 488-conjugated Alpha 1 Antitrypsin Monoclonal antibody
Alpha 1 Antitrypsin Monoclonal Antibody for IF
Host / Isotype
Mouse / IgG1
CoraLite® Plus 488 Fluorescent Dye
Cat no : CL488-66135
|Positive IF detected in
|IF : 1:200-1:800
|It is recommended that this reagent should be titrated in each testing system to obtain optimal results.
|Sample-dependent, check data in validation data gallery
The immunogen of CL488-66135 is Alpha 1 Antitrypsin Fusion Protein expressed in E. coli.
|Host / Isotype
|Mouse / IgG1
|Alpha 1 Antitrypsin fusion protein Ag9516
|serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
|Calculated molecular weight
|418 aa, 47 kDa
|Observed molecular weight
|GenBank accession number
|Gene ID (NCBI)
|CoraLite® Plus 488 Fluorescent Dye
|Excitation/Emission maxima wavelengths
|493 nm / 522 nm
|Protein G purification
|PBS with 50% Glycerol, 0.05% Proclin300, 0.5% BSA, pH 7.3.
|Store at -20°C. Avoid exposure to light. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage. 20ul sizes contain 0.1% BSA.
SERPINA1 is the gene for a protein called alpha-1-antitrypsin (AAT), which is a serine protease inhibitor whose targets include elastase, plasmin, thrombin, trypsin, chymotrypsin, and plasminogen activator. AAT is a glycoprotein synthesized primarily by hepatocytes, with smaller amountssynthesized by intestinal epithelial cells, neutrophils, pulmonary alveolar cells and macrophages. AAT is the most abundant, endogenous serine protease inhibitor in blood circulation and it has been implicated in regulating vital fluid phase biological events such as blood coagulation, fibrinolysis, complement activation, apoptosis, reproduction, tumor progression and inflammatory response. The primary function of AAT is thought to be the inactivation of neutrophil elastase and other endogenous serine proteases. Defects in SERPINA1 can cause emphysema or liver disease.