Amylin Polyclonal antibody, PBS Only

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  IHC staining of human pancreas using 22305-1-AP (same clone as 22305-1-PBS)

  Immunohistochemical analysis of paraffin-embedded human pancreas tissue slide using 22305-1-AP (Amylin Antibody) at dilution of 1:50 (under 10x lens). This data was developed using the same antibody clone with 22305-1-PBS in a different storage buffer formulation.

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  IHC staining of human pancreas using 22305-1-AP (same clone as 22305-1-PBS)

  Immunohistochemical analysis of paraffin-embedded human pancreas tissue slide using 22305-1-AP (Amylin Antibody) at dilution of 1:50 (under 40x lens). This data was developed using the same antibody clone with 22305-1-PBS in a different storage buffer formulation.

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  IHC staining of rat pancreas using 22305-1-AP (same clone as 22305-1-PBS)

  Immunohistochemical analysis of paraffin-embedded rat pancreas tissue slide using 22305-1-AP (Amylin antibody) at dilution of 1:400 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 22305-1-PBS in a different storage buffer formulation.

• 

  IHC staining of rat pancreas using 22305-1-AP (same clone as 22305-1-PBS)

  Immunohistochemical analysis of paraffin-embedded rat pancreas tissue slide using 22305-1-AP (Amylin antibody) at dilution of 1:400 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 22305-1-PBS in a different storage buffer formulation.

• 

  IHC staining of mouse pancreas using 22305-1-AP (same clone as 22305-1-PBS)

  Immunohistochemical analysis of paraffin-embedded mouse pancreas tissue slide using 22305-1-AP (Amylin antibody) at dilution of 1:400 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 22305-1-PBS in a different storage buffer formulation.

• 

  IHC staining of mouse pancreas using 22305-1-AP (same clone as 22305-1-PBS)

  Immunohistochemical analysis of paraffin-embedded mouse pancreas tissue slide using 22305-1-AP (Amylin antibody) at dilution of 1:400 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 22305-1-PBS in a different storage buffer formulation.

Amylin Polyclonal Antibody for IHC, Indirect ELISA

Cat No. 22305-1-PBS

Host / Isotype

Rabbit / IgG

Reactivity

human, mouse, rat

Applications

IHC, Indirect ELISA

Synonyms

IAPP, DAP, Diabetes associated peptide, Diabetes-associated peptide, islet amyloid polypeptide

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Product Information

22305-1-PBS targets Amylin in IHC, Indirect ELISA applications and shows reactivity with human, mouse, rat samples.

• Tested Reactivity: human, mouse, rat
• Host / Isotype: Rabbit / IgG
• Class: Polyclonal
• Type: Antibody
• Immunogen:

  Peptide

• Full Name: islet amyloid polypeptide
• Calculated Molecular Weight: 10 kDa
• GenBank Accession Number: NM_000415
• Gene Symbol: Amylin
• Gene ID (NCBI): 3375
• RRID: AB_2879067
• Conjugate: Unconjugated
• Form: Liquid
• Purification Method: Antigen Affinity purified
• UNIPROT ID: P10997
• Storage Buffer: PBS only, pH 7.3.
• Storage Conditions: Store at -80°C.

Background Information

IAPP, also known as Amylin, is commonly found in pancreatic islets of patients suffering diabetes mellitus type II, or harboring a tumor of the pancreas that is derived from beta cells and secretes INS. IAPP is co-secreted with INS by pancreatic β-cells and largely contributes to glycemic control. Studies suggest that this protein, like the related beta-amyloid (Abeta) associated with Alzheimer's disease, can induce apoptotic cell-death in particular cultured cells, an effect that may be relevant to the development of type II diabetes.