C10orf88 Polyclonal antibody, PBS Only

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• C10orf88 Polyclonal antibody, PBS Only (26026-1-PBS)

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  IP experiment of SH-SY5Y using 26026-1-AP (same clone as 26026-1-PBS)

  IP result of anti-C10orf88 (IP:26026-1-AP, 4ug; Detection:26026-1-AP 1:600) with SH-SY5Y cells lysate 1920 ug. This data was developed using the same antibody clone with 26026-1-PBS in a different storage buffer formulation.

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  IP experiment of HEK-293 using 26026-1-AP (same clone as 26026-1-PBS)

  IP result of anti-C10orf88 (IP:26026-1-AP, 4ug; Detection:26026-1-AP 1:600) with HEK-293 cells lysate 1600 ug. This data was developed using the same antibody clone with 26026-1-PBS in a different storage buffer formulation.

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  IHC staining of rat pancreas using 26026-1-AP (same clone as 26026-1-PBS)

  Immunohistochemical analysis of paraffin-embedded rat pancreas tissue slide using 26026-1-AP (C10orf88 antibody) at dilution of 1:200 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 26026-1-PBS in a different storage buffer formulation.

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  IF Staining of A549 using 26026-1-AP (same clone as 26026-1-PBS)

  Immunofluorescent analysis of (-20°C Methanol) fixed A549 cells using C10orf88 antibody (26026-1-AP) at dilution of 1:200 and CoraLite®488-Conjugated Goat Anti-Rabbit IgG(H+L) (SA00013-2). This data was developed using the same antibody clone with 26026-1-PBS in a different storage buffer formulation.

C10orf88 Polyclonal Antibody for IHC, IF/ICC, IP, Indirect ELISA

Cat No. 26026-1-PBS

Host / Isotype

Rabbit / IgG

Reactivity

human, rat

Applications

IHC, IF/ICC, IP, Indirect ELISA

Synonyms

ATPase PAAT, EC:3.6.1.-, PAAT, Protein associated with ABC transporters

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Product Information

26026-1-PBS targets C10orf88 in IHC, IF/ICC, IP, Indirect ELISA applications and shows reactivity with human, rat samples.

• Tested Reactivity: human, rat
• Host / Isotype: Rabbit / IgG
• Class: Polyclonal
• Type: Antibody
• Immunogen:

  CatNo: Ag22971

  Product name: Recombinant human C10orf88 protein

  Source: e coli.-derived, PET30a

  Tag: 6*His

  Domain: 1-445 aa of BC032645

  Sequence: METRTEDGGLTRRPTLASSWDVAGGALTHSLLLTRAGLGPGDFDWEELLAPPAPGQDLVILKRNHNNKDENPCFLYLRCGPDGGEEIASIGILSSARNMEVYLGEEYCGTSRGKNVCTVLDDSEHEKIILYKKNLKLESSTHACKIKLLSFGERQCVFISKVVVHMRSVFANSSTSSPALGSRIDLDKVQTIMESMGSKLSPGAQQLMDMVRCQQRNCIPIGEQLQSVLGNSGYKHMIGLQSSSTLGTLNKSSSTPFPFRTGLTSGNVTENLQTYIDKSTQLPGGENSTKLDECKVMPQNHSFLENDLKNAMASFLPKKVSDNSNIPNSELLPFLQNLCSQVNHLHVGNKTECQENITKHGERILGVGMEEQSICSYLEKILSKNMELMEKKLMDYIDQRIHELQEHIDDKIALLLDLLQNPNSPPTGIPLRHYDSGERLSNGER

• Full Name: chromosome 10 open reading frame 88
• Calculated Molecular Weight: 445 aa, 49 kDa
• Observed Molecular Weight: 49 kDa
• GenBank Accession Number: BC032645
• Gene Symbol: C10orf88
• Gene ID (NCBI): 80007
• RRID: AB_3742165
• Conjugate: Unconjugated
• Form: Liquid
• Purification Method: Antigen affinity purification
• UNIPROT ID: Q9H8K7
• Storage Buffer: PBS only, pH 7.3.
• Storage Conditions: Store at -80°C.

Background Information

C10orf88 (Chromosome 10 Open Reading Frame 88) is a mitochondria-localized protein that is thought to be associated with protein-binding activity of mitochondria and plays a role in mitochondrial dysfunction and metabolic diseases. Studies suggest that C10orf88 may be involved in cellular metabolism, cell cycle regulation, and maintenance of mitochondrial homeostasis. Its activity is closely related to ATP synthesis and oxidative phosphorylation in mitochondria, and may be affected by a variety of metabolic regulators (e.g., metformin, AICAR) and cell cycle regulators (e.g., rosavitine). In addition, inhibitors of C10orf88 (e.g., oryzanamycin, rotenone) modulate its activity by affecting ATP synthase and electron transport chain complex I in mitochondria.