RESF1 Polyclonal antibody, PBS Only

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• RESF1 Polyclonal antibody, PBS Only (33680-1-PBS)

• 

  WB analysis using 33680-1-AP (same clone as 33680-1-PBS)

  Various lysates were subjected to SDS PAGE followed by western blot with 33680-1-AP (C12orf35 antibody) at dilution of 1:5000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 33680-1-PBS in a different storage buffer formulation.

• 

  WB analysis of K-562 using 33680-1-AP (same clone as 33680-1-PBS)

  WB result of C12orf35 antibody (33680-1-AP; 1:1000; incubated at room temperature for 1.5 hours) with sh-Control and sh-C12orf35 transfected K-562 cells. This data was developed using the same antibody clone with 33680-1-PBS in a different storage buffer formulation.

• Featured Product
• KD/KO Validated

RESF1 Polyclonal Antibody for WB, Indirect ELISA

Cat No. 33680-1-PBS

Host / Isotype

Rabbit / IgG

Reactivity

human

Applications

WB, Indirect ELISA

Synonyms

C12orf35, KIAA1551, Retroelement silencing factor 1

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Product Information

33680-1-PBS targets RESF1 in WB, Indirect ELISA applications and shows reactivity with human samples.

• Tested Reactivity: human
• Host / Isotype: Rabbit / IgG
• Class: Polyclonal
• Type: Antibody
• Immunogen:

  CatNo: Ag38168

  Product name: Recombinant human C12orf35 protein

  Source: e coli.-derived, PGEX-4T

  Tag: GST

  Domain: 1399-1747 aa of BC140819

  Sequence: GSVGATFKLGDSLSNPNERAIVKEKMVSNTKSVDTKASSSKFSRILTPKEYLQRQKHKEALSNKASKKICVKNVPCDSEHMRPSKLAVQVESCGKSNEKHSSGVQTSKESLNGLTSHGKNLKIHHSQESKTYNILRNVKEKVGGKQPDKIWIDKTKLDKLTNISNEAQFSQMPPQVKDQKKLYLNRVGFKCTERESISLTKLESSPRKLHKDKRQENKHKTFLPVKGNTEKSNMLEFKLCPDILLKNTNSVEERKDVKPHPRKEQAPLQVSGIKSTKEDWLKFVATKKRTQKDSQERDNVNSRLSKRSFSADGFEMLQNPVKDSKEMFQTYKQMYLEKRSRSLGSSPVK

• Full Name: chromosome 12 open reading frame 35
• Calculated Molecular Weight: 1747 aa, 195 kDa
• Observed Molecular Weight: 240-250 kDa
• GenBank Accession Number: BC140819
• Gene Symbol: C12orf35
• Gene ID (NCBI): 55196
• RRID: AB_3743047
• Conjugate: Unconjugated
• Form: Liquid
• Purification Method: Antigen affinity Purification
• UNIPROT ID: Q9HCM1
• Storage Buffer: PBS only, pH 7.3.
• Storage Conditions: Store at -80°C.

Background Information

RESF1 (Retroelement Silencing Factor 1, also known as C12orf35 or KIAA1551) is a nuclear protein that primarily mediates the epigenetic silencing of endogenous retroviruses (ERVs) and imprinted genes by interacting with the SETDB1 histone methyltransferase, thereby maintaining H3K9me3 modifications and heterochromatin conformation. Recent studies have revealed that RESF1 exerts metastasis-suppressive functions in estrogen receptor-negative breast cancer. Additionally, RESF1 negatively regulates ribosomal biogenesis and global protein translation, serving as a multifunctional factor that links genome stability, stem cell pluripotency, and tumor suppression.