C8G Recombinant antibody, PBS Only

• 

  WB analysis using 85652-1-RR (same clone as 85652-1-PBS)

  Various lysates were subjected to SDS PAGE followed by western blot with 85652-1-RR (C8G antibody) at dilution of 1:1000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 85652-1-PBS in a different storage buffer formulation.

• 

  WB analysis of human plasma using 85652-1-RR (same clone as 85652-1-PBS)

  human plasma were subjected to SDS PAGE followed by western blot with 85652-1-RR (C8G antibody) at dilution of 1:1000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 85652-1-PBS in a different storage buffer formulation.

C8G Uni-rAb^TM Recombinant Antibody for WB, Indirect ELISA

Cat No. 85652-1-PBS

Clone No.242479G11

Host / Isotype

Rabbit / IgG

Reactivity

human

Applications

WB, Indirect ELISA

Synonyms

C8C

---

Product Information

85652-1-PBS targets C8G in WB, Indirect ELISA applications and shows reactivity with human samples.

• Tested Reactivity: human
• Host / Isotype: Rabbit / IgG
• Class: Recombinant
• Type: Antibody
• Immunogen: C8G fusion protein Ag18261
• Full Name: complement component 8, gamma polypeptide
• Calculated Molecular Weight: 202 aa, 22 kDa
• Observed Molecular Weight: 18-22 kDa
• GenBank Accession Number: BC113626
• Gene Symbol: C8G
• Gene ID (NCBI): 733
• Conjugate: Unconjugated
• Form: Liquid
• Purification Method: Protein A purification
• UNIPROT ID: P07360
• Storage Buffer: PBS only, pH 7.3.
• Storage Conditions: Store at -80°C.

Background Information

The gamma chain of complement component 8 (C8G) is one of three different subunits (alpha, beta, and gamma) of the eighth complement component (C8), which is a component of the MAC (membrane attack complex) (PMID:33382892). Although the roles of C8A and C8B are directly associated with MAC formation, C8G is not essential in the assembly and activity of the MAC (PMID:11960635). Moreover, C8G was shown to inhibit neuroinflammation by interfering with the sphingosine-1-phosphate (S1P)-S1PR2 interaction (PMID:34149451).