Anti-Mouse CD11a (M17/4)

CD11a Monoclonal Antibody for FC

Host / Isotype

Rat / IgG2a, kappa

Reactivity

Mouse

Applications

FC

Conjugate

Unconjugated

CloneNo.

M17/4

Cat no : 65177-1-Ig

Synonyms

Cd11a, integrin alpha L, Itgal, LFA 1, Ly 15, Ly 21

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Validation Data Gallery

• 

  FC experiment of mouse thymocytes using 65177-1-Ig

  1X10^6 mouse thymocytes were surface stained with 0.5 ug Anti-Mouse CD11a (65177-1-Ig, Clone:M17/4) (red), or 0.5 ug Isotype Control. Cells were not fixed.

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Tested Applications

• Positive FC detected in: mouse thymocytes

Recommended dilution

Application	Dilution
This reagent has been tested for flow cytometric analysis. It is recommended that this reagent should be titrated in each testing system to obtain optimal results.
Sample-dependent, Check data in validation data gallery.

Product Information

65177-1-Ig targets CD11a in FC applications and shows reactivity with Mouse samples.

• Tested Reactivity: Mouse
• Host / Isotype: Rat / IgG2a, kappa
• Class: Monoclonal
• Type: Antibody
• Immunogen: C57BL/6 mouse splenic secondary cytotoxic T cells
• Full Name: integrin alpha L
• GenBank Accession Number: BC145802
• Gene Symbol: CD11a
• Gene ID (NCBI): 16408
• RRID: AB_2918452
• Conjugate: Unconjugated
• Form: Liquid
• Purification Method: Purified by protein-A affinity chromatography
• Storage Buffer: PBS with 0.09% sodium azide.
• Storage Conditions: Store at 2-8°C. Stable for one year after shipment.

Background Information

CD11a, also known as integrin αL or LFA-1α, is a 170-180 kDa transmembrane glycoprotein that forms a heterodimer with CD18 (PMID: 7027264; 1672643). CD11a/CD18 (LFA-1) is expressed by all leukocytes and mediates cell adhesion through interactions with its ligands, intercellular adhesion molecule 1 (ICAM-1), ICAM-2, and ICAM-3 (PMID: 7479767). CD11a/CD18 also functions in lymphocyte costimulatory signaling (PMID: 1972160).