65224-1-Ig
Product Information
65224-1-PBS targets CD86 in FC applications and shows reactivity with rat samples.
| Tested Reactivity | rat |
| Host / Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Immunogen |
HTLV-1-transformed Lewis-S1 rat T cell line Predict reactive species |
| Full Name | CD86 molecule |
| Calculated Molecular Weight | 36 kDa |
| GenBank Accession Number | NM_020081 |
| Gene Symbol | Cd86 |
| Gene ID (NCBI) | 56822 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification Method | Protein G purification |
| UNIPROT ID | O35531 |
| Storage Buffer | PBS Only, pH 7.3. |
| Storage Conditions | Store at -80°C. |
Background Information
CD86 (also known as B7.2) is a costimulatory molecule belonging to the immunoglobulin superfamily. Primarily expressed on antigen-presenting cells (APCs), including B cells, dendritic cells, and macrophages, CD86 is the ligand for two proteins at the cell surface of T cells, CD28 antigen and cytotoxic T-lymphocyte-associated protein 4. Binding of CD86 with CD28 antigen is a costimulatory signal for activation of the T-cell. Binding of CD86 with cytotoxic T-lymphocyte-associated protein 4 negatively regulates T-cell activation and diminishes the immune response.
