Cardinal Red™ Anti-Human CD8a (OKT8)
CD8a Monoclonal Antibody for FC
Host / Isotype
Mouse / IgG2a, kappa
Cardinal Red™ Fluorescent Dye
Cat no : CR-65135
|Positive FC detected in
|This reagent has been pre-titrated and tested for flow cytometric analysis. The suggested use of this reagent is 5 ul per 10^6 cells in a 100 µl suspension or 5 ul per 100 µl of whole blood.
|Sample-dependent, check data in validation data gallery
CR-65135 targets CD8a in FC applications and shows reactivity with Human samples.
|Host / Isotype
|Mouse / IgG2a, kappa
|Calculated molecular weight
|235 aa, 26 kDa
|GenBank accession number
|Gene ID (NCBI)
|Cardinal Red™ Fluorescent Dye
|Excitation/Emission maxima wavelengths
|592 nm / 611 nm
|PBS with 0.09% sodium azide and 0.5% BSA.
|Store at 2-8°C. Avoid exposure to light. Stable for one year after shipment.
CD8 is a transmembrane glycoprotein composed of two disulfide-linked chains. It can be present as a homodimer of CD8α or as a heterodimer of CD8α and CD8β (PMID: 3264320; 8253791). CD8 is found on most thymocytes. The majority of class I-restricted T cells express mostly the CD8αβ heterodimer while CD8αα homodimers alone have been found on some gut intraepithelial T cells , on some T cell receptor (TCR) γδ T cells and on NK cells (PMID: 2111591; 1831127; 8420975). CD8 acts as a co-receptor that binds to MHC class-I and participates in cytotoxic T cell activation (PMID: 8499079). During T cell development, CD8 is required for positive selection of CD4-/CD8+ T cells (PMID: 1968084).