Product Information
27498-1-PBS targets CLUL1 in WB, Indirect ELISA applications and shows reactivity with human samples.
| Tested Reactivity | human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen |
CatNo: Ag26570 Product name: Recombinant human CLUL1 protein Source: e coli.-derived, PGEX-4T Tag: GST Domain: 21-124 aa of BC025381 Sequence: APTWKDKTAISENLKSFSEVGEIDADEEVKKALTGIKQMKIMMERKEKEHTNLMSTLKKCREEKQEALKLLNEVQEHLEEEERLCRESLADSWGECRSCLENNC Predict reactive species |
| Full Name | clusterin-like 1 (retinal) |
| Calculated Molecular Weight | 54 kDa |
| Observed Molecular Weight | 70 kDa |
| GenBank Accession Number | BC025381 |
| Gene Symbol | CLUL1 |
| Gene ID (NCBI) | 27098 |
| RRID | AB_3742235 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification Method | Antigen affinity purification |
| UNIPROT ID | Q15846 |
| Storage Buffer | PBS only, pH 7.3. |
| Storage Conditions | Store at -80°C. |
Background Information
Clusterin-like protein 1 (CLUL1) functions as a molecular chaperone, protecting stressed proteins, and is upregulated in various neurodegenerative conditions, suggesting a role in defense against neuronal damage (PMID: 17148042). It is specifically expressed in cone photoreceptor cells and is regulated by the cone-rod homeobox (CRX) (PMID: 14507903). Mutations of CLUL1 were investigated in the context of age-related macular degeneration (AMD), a leading cause of blindness in the elderly (PMID: 17148042).
