Anti-Human CXCL4/PF4 Rabbit Recombinant Antibody

CXCL4/PF4 Uni-rAbTM Recombinant Antibody for FC (Intra)
Cat No. 98410-2-RR
Clone No.243087D5

Host / Isotype

Rabbit / IgG

Reactivity

human

Applications

FC (Intra)

CXCL4, PF4, SCYB4, C X C motif chemokine 4, C-X-C motif chemokine 4

Formulation:  PBS and Azide
PBS and Azide
PBS Only
Conjugate:  Unconjugated
Unconjugated
Size/Concentration: 

-/ -

Freight/Packing: -

Quantity

Please visit your regions distributor:


Tested Applications

Positive FC (Intra) detected inhuman PBMCs

Recommended dilution

ApplicationDilution
Flow Cytometry (FC) (INTRA)FC (INTRA) : 0.25 ug per 10^6 cells in a 100 µl suspension
This reagent has been tested for flow cytometric analysis. It is recommended that this reagent should be titrated in each testing system to obtain optimal results.
Sample-dependent, Check data in validation data gallery.

Product Information

98410-2-RR targets CXCL4/PF4 in FC (Intra) applications and shows reactivity with human samples.

Tested Reactivity human
Host / Isotype Rabbit / IgG
Class Recombinant
Type Antibody
Immunogen CXCL4/PF4 fusion protein Eg2129 Predict reactive species
Full Name platelet factor 4
Calculated Molecular Weight11 kDa
GenBank Accession NumberNM_002619.4
Gene Symbol PF4
Gene ID (NCBI) 5196
Conjugate Unconjugated
Form Liquid
Purification MethodProtein A purification
UNIPROT IDP02776
Storage Buffer PBS with 0.09% sodium azide, pH 7.3.
Storage ConditionsStore at 2 - 8°C. Stable for one year after shipment.

Background Information

CXCL4, also known as platelet factor 4 (PF-4), is the oldest member of the chemokine family. CXCL4 is a chemokine produced by activated platelets and immune cells involved in pathological conditions such as cancer, infections and inflammatory diseases like systemic sclerosis (SSc), rheumatoid arthritis (RA) and psoriatic arthritis (PsA), among others. CXCL4 is present in the α-granules of platelets in amounts that constitute up to 2% platelet protein mass. CXCL4 plays a determinant role in distinct physiological processes such as in hematopoiesis, angiogenesis, coagulation and modulation of immune responses. For instance, CXCL4 can prevent monocyte apoptosis and promote cell survival, induces the production of TNF and reactive oxygen species (ROS) and promotes monocyte differentiation into a unique macrophage-like phenotype.

Protocols

Product Specific Protocols
FC protocol for CXCL4/PF4 antibody 98410-2-RRDownload protocol
Standard Protocols
Click here to view our Standard Protocols
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