Product Information
15568-1-PBS targets DUSP26 in WB, Indirect ELISA applications and shows reactivity with human, mouse, rat samples.
| Tested Reactivity | human, mouse, rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen |
CatNo: Ag7831 Product name: Recombinant human DUSP26 protein Source: e coli.-derived, PGEX-4T Tag: GST Domain: 1-211 aa of BC001613 Sequence: MCPGNWLWASMTFMARFSRSSSRSPVRTRGTLEEMPTVQHPFLNVFELERLLYTGKTACNHADEVWPGLYLGDQDMANNRRELRRLGITHVLNASHSRWRGTPEAYEGLGIRYLGVEAHDSPAFDMSIHFQTAADFIHRALSQPGGKILVHCAVGVSRSATLVLAYLMLYHHLTLVEAIKKVKDHRGIIPNRGFLRQLLALDRRLRQGLEA Predict reactive species |
| Full Name | dual specificity phosphatase 26 (putative) |
| Calculated Molecular Weight | 24 kDa |
| Observed Molecular Weight | 20~24 kDa |
| GenBank Accession Number | BC001613 |
| Gene Symbol | DUSP26 |
| Gene ID (NCBI) | 78986 |
| RRID | AB_3741867 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification Method | Antigen affinity purification |
| UNIPROT ID | Q9BV47 |
| Storage Buffer | PBS only, pH 7.3. |
| Storage Conditions | Store at -80°C. |
Background Information
Dual specificity phosphatase 26 (DUSP26) is an atypical DUSP with a range of physiological substrates including the MAPKs. DUSP26 is highly expressed in neuro-endocrine tissue and is absent in several human cancer cell lines including those derived from brain tumours, neuroblastomas, squamous tumours, lymphoma, colon cancer, non-small cell lung cancer, melanoma, prostatic carcinoma, breast carcinoma and cervical carcinoma (PMID: 33466673, 39222869). DUSP26 exerts a cytoprotective role by selectively dephosphorylating p53 at serine 312. DUSP26 is a 24kda atypical type Ⅰ cysteine-based dual-specificity phosphatase (PMID: 41748589, 35313355).
