Anti-Human DcR2 Rabbit Recombinant Antibody, PBS Only

• 

  FC experiment of human peripheral blood leukocytes using 98412-2-RR (same clone as 98412-2-PBS)

  1x10^6 human peripheral blood leukocytes were surface stained with 0.25 ug Anti-Human DcR2 Rabbit RecAb (98412-2-RR, Clone: 242916D5) or 0.25 ug Rabbit IgG Isotype Control RecAb (98136-1-RR, Clone: 240953C9), and PE-Conjugated Goat Anti-Rabbit IgG(H+L). Cells were incubated with FC Receptor Block prior to staining. Cells were not fixed. This data was developed using the same antibody clone with 98412-2-PBS in a different storage buffer formulation.

• 

  FC experiment of human peripheral blood leukocytes using 98412-2-RR (same clone as 98412-2-PBS)

  1x10^6 human peripheral blood leukocytes were surface stained with 0.25 ug Anti-Human DcR2 Rabbit RecAb (98412-2-RR, Clone: 242916D5) (red) or 0.25 ug Rabbit IgG Isotype Control RecAb (98136-1-RR, Clone: 240953C9) (blue), and PE-Conjugated Goat Anti-Rabbit IgG(H+L). Cells were incubated with FC Receptor Block prior to staining. Cells were not fixed. This data was developed using the same antibody clone with 98412-2-PBS in a different storage buffer formulation.

DcR2 Uni-rAb^TM Recombinant Antibody for FC

Cat No. 98412-2-PBS

Clone No.242916D5

Host / Isotype

Rabbit / IgG

Reactivity

human

Applications

FC

Synonyms

CD264, Decoy receptor 2, TNF-related apoptosis-inducing ligand receptor 4, TNFRSF10D, TRAIL R4

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Product Information

98412-2-PBS targets DcR2 in FC applications and shows reactivity with human samples.

• Tested Reactivity: human
• Host / Isotype: Rabbit / IgG
• Class: Recombinant
• Type: Antibody
• Immunogen: DcR2 fusion protein Eg3487
• Full Name: tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain
• Calculated Molecular Weight: 42 kDa
• GenBank Accession Number: NM_003840.5
• Gene Symbol: DcR2
• Gene ID (NCBI): 8793
• Conjugate: Unconjugated
• Form: Liquid
• Purification Method: Protein A purification
• UNIPROT ID: Q9UBN6
• Storage Buffer: PBS only, pH 7.3.
• Storage Conditions: Store at -80°C.

Background Information

Decoy receptor 2 (DcR2) is a member of the tumor necrosis factor receptor (TNFR) superfamily. It functions as a decoy receptor for TNF-related apoptosis-inducing ligand (TRAIL), thereby inhibiting TRAIL-mediated apoptosis (PMID: 15538968; 9537512). It has been considered a tentative marker of cellular senescence (PMID: 16079833; 22751116). Additionally, DCR2 has been implicated in the regulation of renal fibrosis and cell senescence, contributing to the pathogenesis of diabetic nephropathy (PMID: 35661704).