ESR2 Antibody 0 Publications

Mouse Monoclonal| Catalog number: 60197-1-Ig |CloneNo.: 5D2C9

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Freight/Packing

Con: 150 μg/150 μl

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Species specificity:
human, mouse

Positive WB detected in:
MCF-7 cells, human brain tissue, SW 1990 cells

ApplicationNote:
abc

Recommended dilution:
WB : 1:1000-1:4000

Product Information


Source:
Mouse

Purification method:
Protein G purification

Isotype:
IgG1

Storage:
PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
estrogen receptor 2 (ER beta)

Calculated molecular weight:
59 kDa

Observed molecular weight:
50 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
ESR2

Synonyms
ER BETA, Erb, ESR BETA, ESR2, ESRB, ESTRB, estrogen receptor 2 (ER beta), Estrogen receptor beta, NR3A2
Background

Estrogen receptor-beta (ESR2) is a member of the superfamily of nuclear receptors, which can transduce extracellular signals into transcriptional responses. It binds estrogens with an affinity similar to that of ESR1, and activates expression of reporter genes containing estrogen response elements (ERE) in an estrogen-dependent manner. DNA-binding by ESR1 and ESR2 is rapidly lost at 37 degrees Celsius in the absence of ligand while in the presence of 17 beta-estradiol and 4-hydroxy-tamoxifen loss in DNA-binding at elevated temperature is more gradual. ESR2 exists various isoform and range of calculated molecular weight of isoforms is 50-60 kDa. The experiment detected two bands for ESR2 in isolated human germ cells, one at 60 kDa and a weaker one at 50 kDa (PMID: 14766008).


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